拆分手性化合物色谱填料的研究进展

手性是自然界的一种普遍的现象。不同手性对映体的生理活性差异较大，对手性化合物进行拆分具有十分重要的意义。随着生命、化学、材料的发展，人们对手性化合物的研究也日益深入，色谱法在拆分手性化合物中得到了越来越广泛的应用。作为色谱柱的“心脏”，色谱填料的选择成为了色谱法拆分手性化合物的关键，拆分手性化合物的色谱填料成为人们关注的热点。目前使用的填料主要包括多糖类手性色谱填料、大环手性色谱填料、手性配体交换色谱填料、分子印迹聚合物色谱填料、分子印迹冰胶聚合物色谱填料、“刷型”手性色谱填料、手性金属-有机骨架色谱填料、硅胶键合环果糖色谱填料、蛋白质类手性色谱填料、小粒径色谱填料、免疫亲和色谱填料。本文就拆分手性化合物的色谱填料的研究进展进行综述。

Chirality is a common phenomenon in nature,which is an essential attribute to people's survival. Due to the different chiral enantiomers with different physiological activities,separation of the chiral compounds is of great significance. With the development of life,chemical and material sciences,study of chiral compound are increasingly enhanced and the chromatography has been more and more widely applied in separating chiral compounds. As the "heart" of chromatographic column,the selection of the chromatographic packing is the key to separate chiral compounds. Therefore,the chromatographic packing of separating chiral compounds gradually becomes the hot issue. The chromatographic packing mainly included polysaccharide-based chiral chromatographic packing,macrocyclic chiral chromatographic packing,chiral ligand exchange chromatographic packing, molecularly imprinted polymer chromatographic packing,molecular imprinting cryogel polymer chromatographic packing,brush chiral chromatographic packing,chiral metal-organic framework chromatographic packing,silica supported cyclofructan chromatographic packing,protein-based chiral chromatographic packing,micro size chromatographic packing, and immunoaffinity chromatography packing. In this paper,we systematically reviewed the research progress of chromatographic packing used separation of chiral compounds.

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