ICP-MS法测定维生素B₁注射液中硼、铝、砷、钡、铅的含量

目的:建立同时测定维生素B₁注射液中硼、铝、砷、钡、铅的方法。方法:采用电感耦合等离子体质谱法(ICP-MS)。仪器射频(RF)入射功率为1.3 kW,萃取电压为-143 V,采样深度为65 mm,冷却气流速为13.0 L·min^-1,辅助气流速为0.81 L·min^-1。结果:该方法的加样回收率为95.9%~106.8%,RSD为0.5%~3.5%。被测样品中硼、铝和钡含量偏高。28批样品中硼元素含量为313.4~1028.0 ng·mL^-1,铝元素含量为272.4~863.9 ng·mL^-1,砷元素含量为0~31.0 ng·mL^-1,钡元素含量为115.8~341.0 ng·mL^-1,铅元素含量为3.0~87.8 ng·mL^-1。结论:本方法操作简便、结果可靠,可作为低硼硅玻璃与维生素B₁注射液相容性研究检测方法。

Objective:To establish a method to determine B, Al, As, Ba and Pb in vitamin B₁ injection, so as to control the quality of vitamin B₁ injections.Methods:Vitamin B₁ injections were determined simultaneously by ICP-MS.Incident power was 1.3 kW, the extraction voltage was-143 V, sample depth was 65 mm, the flow rate of plasma gas was 13.0 L·min^-1, and the flow rate of auxiliary gas was 0.81 L·min^-1.Results:The recovery rates of the method were in the range of 95.9%-106.8%, and the RSDs were in the range of 0.5%-3.5%.The analytical results indicated that the contents of B, Al and Ba were at a relatively high level in these samples.The determination results of 28 batches of samples showed that, the content of B was within 313.4-1028.0 ng·mL^-1, the content of Al 272.4-863.9 ng·mL^-1, the content of As 0-31.0 ng·mL^-1, the content of Ba 115.8-341.0 ng·mL^-1, and the content of Pb 3.0-87.8 ng·mL^-1.Conclusion:The established method is proved to be accurate, simple and convenient, which provides a foundation for compatibility study between low borosilicate glass and vitamin B₁ injection.

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