火焰原子吸收光谱法测定药用玻璃的内表面耐水侵蚀性

目的：建立用火焰原子吸收分光光度法测定药用玻璃内表面耐水侵蚀性的方法。方法：加水至玻璃容器满口容量90%，121 ℃保持60 min，用火焰原子吸收分光光度法测定浸提液中钠、钙含量。结果：钠、钙线性范围为0.5~5.0 μg·mL^-1（钠：r＝0.9999，钙：r＝0.9992），检测限分别为0.07、0.1 μg·mL^-1，定量限分别为0.2、0.3 μg·mL^-1，特征浓度分别为0.04、0.09 μg·mL^-1，平均回收率（n=9）分别为102.0%、101.7%。结论：该方法快速、准确、灵敏度高，适于药用玻璃内表面耐水侵蚀性的测定。

Objective: To establish a flame atomic absorption spectrometry method for the determination of hydrolytic resistance of the interior surface of pharmaceutical glass containers. Methods: The glass containers were filled with water to 90% of the brimful capacity and maintained at 121 ℃ for 60 min.The sodium and calcium contents of the extraction solutions were determined by flame atomic absorption spectrometry. Results: The linear ranges of sodium and calcium were 0.5-5.0 μg·mL^-1,(sodium:r=0.9999,calcium:r=0.9992),the detection limits were 0.07 μg·mL^-1 and 0.1 μg·mL^-1,the determination limits were 0.2 μg·mL^-1 and 0.3 μg·mL^-1,the characteristic concentrations were 0.04 μg·mL^-1 and 0.09 μg·mL^-1,and the mean recoveries were 102.0% and 101.7% (n=9). Conclusion: The method is quick,accurate and highly sensitive.It can be used for the determination of hydrolytic resistance of the interior surface of medicinal glass containers.

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