利奈唑胺主要降解产物的结构鉴定
Structure identification of the main degradation products of linezolid
分类号：
出版年·卷·期（页码）：2013,33 (8):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
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目的:对利奈唑胺主要降解产物的结构进行鉴定。方法: 对利奈唑胺原料药进行强力破坏试验,采用高效液相色谱法对降解产物进行分析,应用LC-MS对3个主要的降解产物进行结构鉴定,并利用合成所得杂质对照品对降解产物的结构进行了确证。结果: 3个主要的降解产物分别为利奈唑胺的全水解物、开环水解物以及氨基物。结论: 利奈唑胺在碱性和酸性条件下的降解产物不相同。在碱性条件下的降解产物主要为全水解物和开环水解物,而在酸性条件下的降解产物主要为氨基物。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To identify the structure of the main degradation products of linezolid. Methods: Stress destruction testing was applied to the crude drug of linezolid,with an HPLC method to analyze the degradation products.The three main degradation products were identified by LC-MS,and the structure of them were confirmed through comparison with synthetic impurities. Results: Three main degradation products are the full hydrolysate,the ring-opening hydrolysate and the amido substance of linezolid. Conclusion: The alkaline hydrolysis products of linezolid are different from the acid hydrolysis product.The main alkaline hydrolysis products are the full hydrolysate and the ring-opening hydrolysate,while the acid hydrolysis product is the amido substance.
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