商品苦参根茎研究简述

商品苦参中具髓束的苦参为豆科植物苦参Sophora flavescens Ait.的根茎;苦参根与根茎并存,根茎已是主要来源;苦参根茎中苦参碱和氧化苦参碱总量符合中国药典2010年版规定。本文对中国药典2010年版(一部)规定的苦参药用部分为根,但性状项下既有根也有根茎的叙述进行了讨论,简述商品苦参根茎的研究结果,建议再版中国药典时将苦参根茎正式列入苦参药用部分。

The commodity Kushen which has medullary bundles is the rootstock of Sophora flavescens Ait.(fam.Leguminosae).The rootstocks and roots of Kushen coexist in commercial drug,but the rootstocks have been the main source.The total contents of matrine and oxymatrine in Kushen's rhizomes meet the standards in ChP(Vol Ⅰ)2010 Ed.Here we discussed about the fact that the effective part of Kushen for medical use is only the root as mentioned in ChP(Vol Ⅰ)2010 Ed,but the depiction under the characteristic part is both root and rootstock.This paper summarizes the studies on commodity Kushen's rootstock and suggested that the rhizome of Sophora flavescens Ait.should be adopted formally into the new edition of Chinese Pharm acopoeia as an effective part of Kushen for medical use.

1 Institute of Materia Medica,Chinese Academy of Medical Science and Peking U nion Medical College(中国医学科学院药物研究所等).Zhongyaozhi(中药志).Vol Ⅰ(第一册).Beijing(北京):People's Medical Publishing House(人民卫生出版社),1979.193
2 ZHANG Ping(张萍).A newly appeared obscured product of Kushen herbs pieces(商品苦参中新出现的混淆品).Chin J Pharm Anal(药物分析杂志),1996,16(5):331
3 ZHANG Ping(张萍),LI Jiu-dan(李九丹).Comparative study on Kushen's root and rootstock(苦参根和根茎的比较研究).Chin J Pharm Anal(药物分析杂志),2004,24(3):327
4 JIN Shu-qin(金淑琴).A study on unusual structure of root of light yellow Sophora(苦参异常构造的研究). Cap Med(首都医药),1999,6(8):26
5 PAN Lu-min(潘鲁敏).The addendum for Kushen tissue's structure(苦参组织构造补遗).Chin Tradit Herb Drugs(中草药),2001,32(12):1129
6 ZHANG Ping(张萍),LI Jiu-dan(李九丹).Investigation on the condition of medical use of rootstock of the commodity Kushen(商品苦参中根茎药用情况调查).Chin J Pharm Anal(药物分析杂志),2010,30(11):2093
7 ZHU Li-jun(朱丽君),LIU Bin(刘斌).Quantitative determination of four components in alkaloid fraction of Sophora flavescens Ait.by HPLC(HPLC法测定苦参生物碱部位中4种成分含量).J Beijing Univ Tradit Chin Med(北京中医药大学学报),2007,30(11):780
8 WANG Wen-lai(汪文来),ZHAO Hong-xia(赵红霞),JIA Hai-hua(贾海骅),et al.Determination of matrine and Oxymatrine in Sophora flavescens from different regions by HPLC(HPLC法测定不同产地苦参中苦参碱和氧化苦参碱的含量).Chin J Basic Med Tradit Chin Med(中国中医基础医学杂志),2007,13(10):799
9 ZHANG Ping(张萍),YANG Lu(杨璐),HAN Nan-yin(韩南银),et al.HPLC-DAD determination of 5 alkaloids in commercial available Kushen's rhizome and root(HPLC-DAD法测定商品苦参根茎和根中5个生物碱含量).Chin J Pharm Anal(药物分析杂志),2011,31(12):2294
10 ZHANG Ping(张萍),YANG Lu(杨璐),HAN Nan-yin(韩南银),et al.HPLC-DAD determination of 5 alkaloids in self-collecting Kushen^,s rhizome and root(HPLC-DAD法测定自采苦参根茎和根中5个生物碱含量). Chin J Pharm Anal(药物分析杂志),2012,32(3):512
11 ChP(中国药典).2000.VoI Ⅰ(一部):161
12 ChP(中国药典).2005.VoI Ⅰ(一部):141
13 ChP(中国药典).2010.VoI Ⅰ(一部):188
14 ZHANG Ping(张萍),LI Jiu-dan(李九丹).The discussion "Kushen's medical effective Part" adopted in ChP(Vol Ⅰ)2005 Ed. Chin J Pharm Anal(药物分析杂志),2006,26(11):1597
15 LOU Zhi-cen(楼之岑),QIN Bo(秦波).Species systematization and quality evaluation of commonly used Chinese traditional drugs(常用中药材品种整理和质量研究).North-China Edition,Volume Ⅰ(北方编,第一册).Beijing(北京):Peking Union Medical College and Beijing Medical University Press(北京医科大学中国协和医科大学联合出版社),1995.343