核磁共振和液相色谱-质谱法对多索茶碱未知杂质的结构分析

目的:建立利用仪器分析多索茶碱未知杂质化学结构的方法。 方法:应用HPLC-MS/MS、核磁共振(¹H-NMR、¹³C-NMR、HMBC)技术,对多索茶碱及其未知杂质进行结构分析。 结果:首次发现并确定多索茶碱未知杂质的结构。 结论:该方法可为多索茶碱的质量控制提供依据。

Objective: To establish a method for the determination of the chemical structure of an unknown impurity in doxofylline. Methods: HPLC-MS/MS and nuclear magnetic resonance(¹H-NMR,¹³C-NMR,HMBC) were adopted to analyze the chemical structure of doxofylline and its impurities. Results: The chemical structure of the unknown impurity was determined and identified. Conclusion: The established method can provide a comprehensive reference for quality control of doxofylline.

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