目的: 对比分析中国药典和欧洲药典银杏叶提取物(EGB)中银杏酸(GA)限度的检测方法,为新版中国药典标准提供参考意见。方法: 采用中国药典和欧洲药典的检测方法进行EGB中GA的限度检测研究,详细对比分析研究结果,寻找差异规律。结果: 由于样品前处理方法、色谱条件及计算方法的不同,银杏酸限度测定结果显示,欧洲药典的方法测定值较中国药典方法测得值高。结论: 中国药典和欧洲药典中GA检测方法存在较大差异,需要结合各种方法的优点,建立一种更准确、可靠的GA限度检测方法。
Objective: To compare ginkgolic acid(GA)limited test methods of Ginkgo biloba extract(EGB)in Chinese Pharmacopoeia(ChP)and European Pharmacopoeia(EP)in order to provide reference for the new ChP edition.Methods: ChP and EP detection methods were used to determine ginkgolic acid limit tests of Ginkgo biloba extract,the detailed analysis results were compared,and the law of the differences was investigated.Results: Because of the differences in the sample pretreatment methods,chromatographic conditions and calculation methods,ginkgo acid limit measurement results showed that the determined value by the EP method was higher compared to the ChP method.Conclusion: There is great difference about test methods and analytical results of ginkgolic acid in Ginkgo biloba extract between ChP and EP.It is necessary to develop a more accurate,more reliable limit detection method of ginkgolic acid combining with the advantages of each method.
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