米诺膦酸的多晶型及热稳定性研究

目的: 建立米诺膦酸的多晶型及热稳定性的研究方法。 方法: 通过热重分析和X射线衍射及其原位高温装置对米诺膦酸的多晶型及在加热过程中的晶型稳定性进行检测与分析。 结果: 米诺膦酸存在一水、半水和无水结晶结构,一水米诺膦酸在加热过程中晶型会发生改变,分步失去结晶水后转变为无水米诺膦酸。 结论: 该方法操作简单,重复性好,能够为寻找药物新晶型提供方法。

Objective: To establish a method for study of polymorphism and themostability of minodronic acid. Methods: The thermostability of minodronic acid was evaluated by thermogravimetric analyzer(TGA),and crystal structure was analyzed by X-ray diffraction(XRD) with in-situ high temperature accessories. Results: The minodronic acid showed different crystal forms of monohydrate,hemihydrate and anhydrate.Minodronic acid monohydrate would lose their crystal water during the heating process,and its crstal would change into anhydrate crystal. Conclusion: The method is simple and reproducible,which can be used to study the new drug crystal structures.

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