硫普罗宁注射液其他杂质的结构分析
Structure identification of the other impurities in tiopronin injection
分类号：
出版年·卷·期（页码）：2012,32 (4):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的: 确证硫普罗宁注射液中2个较大杂质的结构。 方法: 利用HPLC和LC-MS等方法确证结构。 结果: 确证两未知杂质结构为:2-巯基丙酸和N-(2-氯丙酰基)-甘氨酸。 结论: 2个杂质的结构确定,为硫普罗宁生产工艺的改进及选择合适的运输、储存条件提供了重要信息。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To elucidate two impurities in tiopronin injections. Method: two related impurities were identified with HPLC and LC-MS. Results: Two unknown impurities were confirmed to be 2-mercaptopropionic acid and N-(2-chloro carbonyl)-glycine. Conclusion: Confirmed the structure of two impurities,provide important information for the production process of tiopronin improvements and the selection of the appropriate transport and storage conditions.
-----参考文献：---------------------------------------------------------------------------------------
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