马来酸罗格列酮的表面增强拉曼光谱研究

目的: 研究马来酸罗格列酮在不同激发光波长以及不同酸碱度条件下的表面增强拉曼光谱,对表面增强拉曼光谱中的分子振动模式进行识别。 方法: 用3种不同的激发光波长对不同pH条件下马来酸罗格列酮的表面增强拉曼散射(SERS)进行考察,推测分子在纳米颗粒上的吸附取向、成键方式,对增强机制作出推断。 结果: 研究表明,药物分子-银胶体系的pH对马来酸罗格列酮的增强效应有较大的影响,这是pH对药物分子-银胶体系的凝聚状态和马来酸罗格列酮分子存在状态综合影响的结果。另外,激发光波长对马来酸罗格列酮的SERS效应也有很大的影响,这体现了光源对药物分子-银胶体系的选择性激发。 结论: 本方法简单、快速、可靠,专属性强,可以作为分析马来酸罗格列酮分子在纳米表面吸附情况的方法。

Objective: To study the surface enhanced Raman scattering(SERS) of rosiglitazone maleate on the acidic/basic condition and under various optical luminescences, and identify the pattern of molecule vibration by SERS. Methods: Three kinds of excitation wavelengths under different pH conditions was adopted for study of the SERS of rosiglitazone mleate, and to infer the enhancing mechanism according to the absorbing orientation and chemical bond production of nanoparticles material. Results: Results showed that the pH of the system had obvious effect on the SERS,it was resulted from the total influence of the pH on the coacervation of the nanoparticles sol and existent form of the rosiglitazone maleate.The optical luminescences also had a lot effection on the SERS,it reflected the selective excitation of the source to drug molecules-silver colloid system. Conclusion: The method is reliable,rapid,accurate and specific, and can be a method to analyze the absorption of rosiglitazone maleate on the surface of nanoparticles.