醛酮类药用辅料的振动光谱分析

目的: 建立醛酮类药用辅料的拉曼光谱分析方法。 方法: 采集了几种醛酮类药用辅料的红外光谱和拉曼光谱,分别归属其振动光谱峰并分析比较光谱差异与结构之间的关系。 结果: 和红外光谱一样,拉曼光谱可以给出关于化合物结构的指纹信息,并可和红外光谱相互补充佐证。 结论: 建立的方法快速、简便、专属性强,可用于醛酮类药用辅料的鉴别。

Objective: To develop a Raman spectra method for the analysis of aldehydes and ketones excipients. Methods: IR spectra and Raman spectra of the excipients were collected, respectively, and the attribution of the observed frequencies in the spectra and their association with specific modes of vibration were assigned. According to the structure, the similarities and differences among them were studied by comparing. Results: Raman spectra, similart and complementary to IR spectra, can give the finger prints information about the corresponding structure. Conclusion: The method is rapid, simple and specific for the qualitative analysis of pharmaceutical excipients.