常用羧酸类及其衍生物药用辅料的拉曼光谱鉴别___
Qualitative analysis of carboxylic acids and derivatives
分类号：
出版年·卷·期（页码）：2010,30 (3):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的：建立羧酸类及其衍生物药用辅料的拉曼光谱定性鉴别方法。方法：收集常用羧酸类及其衍生物药用辅料的拉曼光谱，对拉曼光谱峰进行指认，分析比较了结构和光谱差异之间的关系。结果：拉曼光谱可以给出关于化合物结构的指纹信息，并可和红外光谱相互补充佐证。结论：建立的方法快速、简便、专属性强，可用于羧酸类及其衍生物药用辅料的鉴别。
-----英文摘要：---------------------------------------------------------------------------------------
Aim：To develop a Raman spectroscopy method for the qualitative analysis of the carboxylic acids and derivatives commonly used as pharmaceutical excipients.Methods: Raman spectra of the carboxyl and related excipients were collected, the attribution of the observed frequencies in the spectra and their association with specific modes of vibration were assigned. According to the structure, the similarities and differences among them were studied by comparing. Results: Raman spectra, similar to and complementary to IR spectra, can give the finger prints information about the corresponding structure. Conclusion: The method is rapid, simple and specific for the qualitative analysis of pharmaceutical excipients.
-----参考文献：---------------------------------------------------------------------------------------
1．Attention to the adverse reactions resulting from pharmaceutical excipients（关注药用辅料引起的不良反应）. China Pharmaceutical Technology Exchange（中国医药技术与市场），2006，6 (3)：55 2．GRASSELLI J G，WALDER F，PETTYC，et al. Industrial applications of Raman spectroscopy. Journal of Molecular Structure，1993，294：207 3．ZHANGYan-hui（张延会），WU Liang-ping（吴良平），SUN Zhen-rong（孙真荣）. Development of the research on the application of Raman Spectroscopy（拉曼光谱技术应用进展）
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