Objective:To compare the effectiveness of different dosage and administration ways on the platelet function (PAC-1) and fibrinolytic system(PAI-1,T-PA) of patients with ACS.Methods:From January 2008 to December 2008；60 patients with ACS are enrolled in this study.All patients are given the drugs of regular and are divided into 3 groups depending on the different dosage and administration ways, plasma PAC-1,PAI-1,T-PA content were measured at pre-treatment and post-treatment.Results：①In ACS at pre-treatment, the level of PAC-1, PAI-1,T-PA are higher than that of health control group(P＜0.01), and the changes of these markers are more significantly in AMI patients than UAP patients(P＜0.05);②After the therapy,in the clopidogrel routine dosage group and aspirin group,PAC-1,PAI-1 are lower than that of blank control group(P＜0.05) and T-PA is highter(P＜0.05); After the therapy,in routine dosage group and aspirin group, PAC-1, PAI-1 are lower than pre-treatment(P＜0.05) and T-PA is highter(P＜0.05)；After the therapy, in the clopidogrel routine dosage group, PAC-1, PAI-1 are much lower than that of aspirin group and T-PA is much highter(P＜0.05);③After the therapy, in AMI combination group, PAC-1, PAI-1 are lower than pre-treatment(P＜0.05) and T-PA is highter(P＜0.05);④In ACS at post-treatment, the changes of these markers are more significantly than control group(P＜0.05)Conclusion：①PAC-1 is the one of sensitive markers representing the severity of coronary heart diseases; ②T-PA/PAI-1 are the sensitive markers of fibrinolytic system in ACS;③The long-time use of routine dosage clopidogrel may improve the activity of fibrinolytic system of ACS patients.
