药品、食品中反式脂肪酸的研究进展___

摘要：本文综述了反式脂肪酸的结构、来源、危害、分析方法和国外标准，并建议对相关药品中可能存在的反式脂肪酸进行考察。

Abstract:We had a review on the structure,origin,harmfulness,analytical methods and foreign standards of trans fatty acids,and advised to determinate trans fatty acids in relevant drugs.

1Sally F Schakel,Lisa Harnack1,Christine Wold,et al.Incorporation of trans-fatty acids into a comprehensive nutrient database. J Food Composi Anal,1999,12(4):323
2William W Christie.A practical guide to the analysis of conjugated linoleic acid (CLA).Inform,2001,12:147
3Robert L Wolff.Content and distribution of trans-18:1 acids in ruminant milk and meat fats.Their importance in European diets and their effect on human milk.JAOCS,1995,72(3):259
4G S M J E Duchateau,H J Van Oosten,M A Vasconcellos.Analysis of cis-and trans-fatty acid isomers in hydrogenated and refined vegetable oils by capillary gas-liquid chromatography.JAOCS,1996,73(3):275
5Manuela Buchgraber,Franz Ulberth.Determination of low level trans unsaturation in physically refined vegetable oils by capillary GLC results of 3 intercomparison studies.Eur J Lipid Sci Technol,2002,104 (12):792
6Ronald P Mensink,Peter L Zock,Arnold DM Kester,et al.Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins：a meta-analysis of 60 controlled trials.Am Soc Clin Nutri,2003,77(5):1146
7Harding AH,Day NE,Khaw KT,et a1.Dietary fat and the risk of clinical type 2 diabetes:The European prospective investigation of cancer-norfolk study.Am J Epidemiol,2004,159(1):73
8T Sepp nen-Laakso,I Laakso,R Hiltunen.Analysis of fatty acids by gas chromatography,and its relevance to research on health and nutrition.Anal Chim Acta,2002,465(1-2):39
9Jean Michel Chardigny,Robert L Wolff,Estelle Mager,et al.Fatty acid composition of French infant formulas with emphasis on the content and detailed profile of trans fatty acids.JAOCS,1996,73(11):1595
10Hormoz Aziziana,John K G Kramer.A rapid method for the quantification of fatty acids in fats and oils with emphasis on trans fatty acids using Fourier transform near infrared spectroscopy (FT-NIR).Lipids,2005,40(8):855
11W M Nimal Ratnayake,Steven L Hansen,Michael P Kennedy.Evaluation of the CP-Sil 88 and SP-2560 GC columns used in the recently approved AOCS official method Ce 1 h-05:Determination of cis-,trans-,saturated,monounsaturated,and polyunsaturated fatty acids in vegetable or non-ruminant animal oils and fats by capillary GLC method.JAOCS,2006,83(6 ):475
12Alfred A Christy,Per K Egeberg,Eilif T stensen.Simultaneous quantitative determination of isolated trans fatty acids and conjugated linoleic acids in oils and fats by chemometric analysis of the infrared profiles.Vib Spectrosc,2003,33(1-2):37
13William W Christie.Gas chromatography mass spectrometry methods for structural analysis of fatty acids. Lipids, 1998,33(4):343
14A Bysted,S Cold,G Helmer.An optimized method for fatty acid analysis,including quantification of trans fatty acids,in human adipose tissue by gas-liquid chromatography.Scand J Clin Lab Invest,1999,59(3):205
15Andre′ Muller,Hans Steinhart.Recent developments in instrumental analysis for food quality.Food Chem,2007(3),101:1136
16Shu Hui Chen,Kwan Cheng Chen,Hsiang Mei Lien.Determination of fatty acids in vegetable oil by reversed-phase liquid chromatography with fluorescence detection.J Chromatogr A,1999,849(2):357
17Oliverira M A,Solis V E,GioleUi L A,et a1.Method development for the analysis of trans-fatty acids in hydrogenated oils by capillary electrophoresis.Electrophoresis,2003,24(10):1641
18DENG Da-ming(邓大明),ZHU Jing-ping(祝经平).Refinement of soybean oil for fat emulsion injection(脂肪乳注射液用大豆油的精制法).Chin Pharm J(中国药学杂志),2000,35(1):26
19L Jing(吕晶),CHEN Gang(陈钢).Determination of trans fatty acids in lipid emulsion by methylation-capillary GC(脂肪乳剂中的反式脂肪酸的甲酯化－毛细管气相色谱法测定).Chin J Pharm(中国医药工业杂志),2008,39(4):276