对肺癌患者和健康人尿液中9种微量元素的判别分析___
The comparative research of trace elemental concentration contents in human urine from lung cancer patients and healthy people discriminant analysis
分类号：
出版年·卷·期（页码）：2009,29 (6):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
摘要 目的：对肺癌患者和健康人尿液中9种微量元素进行判别分析，为肺癌的早期诊断提供科学依据。方法：用电感耦合等离子体发射光谱法测定肺癌患者和健康人尿液中的铬、铁、锰、铝、镉、铜、锌、镍，用原子荧光光谱法测定硒。结果：各元素线性关系良好，回归系数为0.9990~0.9998，检出限为0.0004~0.03 μg•mL-1，方法精密度为1.9%~9.0%，加标回收率为80.1%~120.0%。对肺癌患者和健康人尿液中9种微量元素的含量进行了判别分析，建立判别函数，误判率小于2%。结论：肺癌患者和健康人尿液中9种微量元素的综合水平存在较为显著的差别。
Key words:
-----英文摘要：---------------------------------------------------------------------------------------
AbstractObjectives:To classify the concentrations of elements existing in the urine from lung cancer patients and healthy people by using discriminant analysis and afford the data for the early diagnosis of lung cancer.Methods:The concentrations of Cr,Fe,Mn,Al,Cd,Cu,Zn,Ni in human urine from lung cancer patients and healthy people in Shenyang were determined by inductively coupled plasma atomic emission spectrometry.Se was determined by atomic fluorescence spectrometry.Results:The standard curves were linear over working ranges and gave average correlation coefficients between 0.9990-0.9998.The limits of determination (LOD) were 0.0004-0.03 g•mL-1.The precisions were between 1.9%-9.0%,and the recoveries were between 80.1%-120.0%.The odds of erroneous judgement is lower than 2%.Conclusion:A data matrix of concentration of elements existing in the urine from lung cancer patients and healthy people are classified by using discriminant analysis.It shows that there is considerable difference between them.
-----参考文献：---------------------------------------------------------------------------------------
1HU Zhen-hua（胡振华），REN Qun（任群），GUO Jian（郭键），et al.Significance of determination of serum zinc,copper and copper/zinc ratio on evaluating diagnosis therapeutic effect and prognosis of lung cancer（血清锌、铜与铜/锌比值对肺癌诊断、疗效和预后判断的临床意义）.Guangdong Trace Elem Sci（广东微量元素科学），2000，7（1）：19
2ZHANG Zhuo-yong（张卓勇），ZHOU Hua-lan（周化岚），LIU Si-dong（刘思东）.Bidirectional associative memory and its application to classification of lung cancer patients（双向联想记忆神经网络及其在肺癌患者分类判别中的应用）.Spectrosc Spectral Anal（光谱学与光谱分析），2002，22（2）：341
3LUO Xu（罗旭）.Chemstatistics（化学统计学）.Beijing（北京）：Science Press（科学出版社），2001.366
4HE Xiao-qun（何晓群）.Modern Statistical Analysis and Application（现代统计分析方法与应用）.Beijing（北京）：China Peoples University Press（中国人民大学出版社），1998.252
欢迎阅读《药物分析杂志》！您是该文第 2065位读者！
