[1] 邓爱平.牡丹皮质量评价及商品规格研究[D].广州:广东药科大学,2018 DENG AP.Research of Quality Evaluation and Commercial Grades of Moutan Cortex[D].Guangzhou:Guangdong Pharmaceutical University,2018
[2] 中华人民共和国药典2015年版.一部[S].2015:28,55,56,58,72,103,105,281,289 ChP 2015.VolⅠ[S].2015:28,55,56,58,72,103,105,281,289
[3] XU SJ,YANG L,ZENG X,et al.Characterization of compounds in the Chinese herbal drug Mudanpi by liquid chromatography coupled to electrospray ionization mass spectrometry[J].Rapid Commun Mass Spectrom,2006,20(22):3275
[4] WANG XH,XIE PS,LAM CW,et al.Study of the destructive effect to inherent quality of Angelicae Dahuricae Radix (Baizhi) by sulfur-fumigated process using chromatographic fingerprinting analysis[J].J Pharm Biomed Anal,2009,49(5):1221
[5] LI SL,SHEN H,ZHU LY,et al.Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs,a case study on white ginseng[J].J Chromatogr A,2012,1231:31
[6] KANG C,LAI CJ,ZHAO D,et al.A practical protocol for comprehensive evaluation of sulfur-fumigation of Gastrodiae Rhizoma using metabolome and health risk assessment analysis[J].J Hazard Mater,2017,340:221
[7] SUN X,CUI XB,WEN HM,et al.Influence of sulfur fumigation on the chemical profiles of Atractylodes macrocephala,Koidz.evaluated by UFLC-QTOF-MS combined with multivariate statistical analysis[J].J Pharm Biomed Anal,2017,141:19
[8] BRAVEMAN JBS,KOPELMAN J.Sugar sulfonates and their behavior[J].J Food Sci,1961,26(3):248
[9] BRAVERMAN JBS.The mechanism of the interaction of sulphur dioxide with certain sugars[J].J Sci Food Agric,1953,4(11):540
[10] 赵锦燕.炮山甲二氧化硫残留量超标原因分析与探讨[D].杭州:浙江中医药大学,2015 ZHAO JY.The Causal Analysis and Research for Residual Quantity of Sulfur Dioxide Above Standards in Pangolin Scales[D].Hangzhou:Zhejiang Chinese Medical University,2015
[11] 李林,张志杰,蔡宝昌.硫熏对百合有效成分的影响[J].上海中医药大学学报,2006,20(1):64 LI L,ZHANG ZJ,CAI BC.Effect of sulphur fumigation on the effective components of lily[J].Acta Univ Tradit Med Sin Pharmacol Shanghai,2006,20(1):64
[12] 魏黎阳.硫磺熏蒸对兰州百合品质的影响[D].兰州:兰州理工大学,2017 WEI LY.Study on Effects of Sulfur Fumigation on the Quality of Lilium davidii[D].Lanzhou:Lanzhou University of Technology,2017
[13] 崔援军,辛爱玲.硫磺熏制对山药多糖含量的影响[J].安徽医药,2007,11(12):1101 CUI YJ,XIN AL.Effect of sulphur fuming on the contents of polysaccharide in Dioscorea opposita Thunb.[J].Anhui Med Pharm J, 2007,11(12):1101
[14] FAN G,DENG R,ZHOU L,et al.Development of a rapid resolution liquid chromatographic method combined with chemometrics for quality control of Angelicae Dahuricae Radix[J].Phytochem Anal,2012,23(4):299
[15] 卢晓琳.硫黄熏蒸对白芷化学成分、药效和安全性影响的研究[D].成都:成都中医药大学,2013 LU XL.Research on the Effects of Chemical Composition,the Efficacy and Safety of Angelica dahurica by Sulfur-fumigation[D].Chengdu:Chendu University of TCM,2013
[16] LIU X,LIU J,CAI H,et al.Novel characterization of Radix Angelicae Dahuricae before and after the sulfur-fumigation process by combining high performance liquid chromatographic fingerprint and multi-ingredients determination[J].Pharmacogn Mag,2014,10(39):338
[17] 李友连,王珊,朱晶晶,等.硫磺熏蒸对亳菊化学成分的影响[J].中国中药杂志,2015,40(13):2624 LI YL,WANG S,ZHU JJ,et al.Study on effects of sulfur fumigation on chemical constituents of Chrysanthemum morifolium cv.Boju[J].China J Chin Mater Med,2015,40(13):2624
[18] 郁红礼,张倩,金羊平,等.硫熏和直接热风加热的粉葛中葛根素含量及药效的比较研究[J].中国中药杂志,2016,41(14):2571 YU HL,ZHANG Q,JIN YP,et al.Comparison of sulfur fumigation processing and direct hot air heating technology on puerarin contents and efficacy of Puerariae Thomsonii Radix[J].China J Chin Mater Med,2016,41(14):2571
[19] YANG M,ZHOU Z,GUO DA.A strategy for fast screening and identification of sulfur derivatives in medicinal Pueraria species based on the fine isotopic pattern filtering method using ultra-high-resolution mass spectrometry[J].Anal Chim Acta,2015,894:44
[20] 季琳,毛春芹,陆兔林,等.不同加工方法对黄芪有效成分含量及二氧化硫残留量的影响[J].中国中药杂志,2014,39(15):2819 JI L,MAO CQ,LU TL,et al.Effect of differet processing methods on active ingredient contents and sulfur dioxide residue in Astragali Radix[J].China J Chin Mater Med,2014,39(15):2819
[21] 翟宇瑶,胡明勋,陈安家,等.硫磺熏蒸对黄芪中黄酮类和皂苷类成分的影响[J].现代药物与临床,2014,29(5):489 ZHAI YY,HU MX,CHEN AJ,et al.Effects of sulphur fumigation on flavonoids and saponins in Astragali Radix[J].Drugs Clin,2014,29(5):489
[22] 靳灿灿,李会军.硫磺熏蒸对天麻有效成分的影响[J].中成药,2014,36(8):1706 JIN CC,LI HJ.Effect of sulfur fumigation on active components in Gastrodiae Rhizoma[J].Chin Tradit Pat Med,2014,36(8):1706
[23] ZHANG X,NING Z,JI D,et al.Approach based on high-performance liquid chromatography fingerprint coupled with multivariate statistical analysis for the quality evaluation of Gastrodiae Rhizoma[J].J Sep Sci,2015,38(22):3825
[24] 康传志,杨婉珍,周利,等.不同产地和变型天麻药材的质量及其硫磺熏蒸前后的变化[J].中国中药杂志,2018,43(2):254 KANG CZ,YANG WZ,ZHOU L,et al.Quality changes in Gastrodiae Rhizoma of different origins and forms before and after sulfur fumigation[J].China J Chin Mater Med,2018,43(2):254
[25] CAI H,CAO G,LI L,et al.Profiling and characterization of volatile components from non-fumigated and sulfur-fumigated Flos Lonicerae Japonicae using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry coupled with chemical group separation[J].Molecules,2013,18(2):1368
[26] 郭爱丽,高慧敏,陈两绵,等.硫磺熏蒸金银花中断马钱子酸亚硫酸衍生物产生的机制探讨[J].中国中药杂志,2014,39(9):1639 GUO AL,GAO HM,CHEN LM,et al.Investigation on formation mechanism of secologanic acid sulfonates in sulfur-fumigated buds of Lonicera japonica[J].China J Chin Mater Med,2014,39(9):1639
[27] 王亚君,郭巧生,杨秀伟,等.小亳菊及其硫磺熏制品挥发油成分的GC-MS分析[J].中国中药杂志,2007,32(9):808 WANG YJ,GUO QS,YANG XW,et al.GC-MS analysis of essential oil from Xiaoboju processed by aeration-desiccation and sulfur-burnin fumigation[J].China J Chin Mater Med,2007,32(9):808
[28] KONG M,LIU HH,XU J,et al.Quantitative evaluation of Radix Paeoniae Alba sulfur-fumigated with different durations and purchased from herbal markets:simultaneous determination of twelve components belonging to three chemical types by improved high performance liquid chromatography[J].J Pharm Biomed Anal,2014,98(10):424
[29] 王巧,刘荣霞,郭洪祝,加工炮制对白芍化学成分的影响[J].中国中药杂志,2006,31(17):1418 WANG Q,LIU RX,GUO HZ.Study on influence of processing methods on chemical constituents in Radix Paeoniae Alba[J].China J Chin Mater Med,2006,31(17):1418
[30] 王赵,陈玉武,王琼,等.硫熏白芍的质量评价[J].中国中药杂志,2014,39(16):3074 WANG Z,CHEN YW,WANG Q,et al.Quality assessment of sulfur-fumigated Paeoniae Alba Radix[J].China J Chin Mater Med,2014,39(16):3074
[31] ZHANG J,CAI H,CAO G,et al.Exploring potential chemical transformation by chemical profiling approach for rapidly evaluating chemical consistency between sun-dried and sulfur-fumigated Radix Paeoniae Alba using ultra performance liquid chromatography coupled with time-of-flight mass[J].Evid Based Complement Alternat Med,2013(10):763213
[32] LI SL,SONG JZ,CHOI FF,et al.Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry[J].J Pharm Biomed Anal,2009,49(2):253
[33] ZHAN ZL,DENG AP,KANG LP,et al.Chemical profiling in Moutan Cortex after sulfuring and desulfuring processes reveals further insights into the quality control of TCMs by nontargeted metabolomic analysis[J].J Pharm Biomed Anal,2018,156:340
[34] 李成义,魏学明,王明伟,等.硫熏对党参中党参炔苷含量的影响[J].中国现代中药,2010,12(12):11 LI CY,WEI XM,WANG MW,et al.Effect of sulphur fumigation on lobetyolin in Codonopsis Radix[J].Mod Chin Med,2010,12(12):11
[35] MA XQ,LEUNG AK,CHAN CL,et al.UHPLC UHD Q-TOF MS/MS analysis of the impact of sulfur fumigation on the chemical profile of Codonopsis Radix (Dangshen)[J].Analyst,2014,139(2):505
[36] MA XQ,LI SM,CHAN CL,et al.Influence of sulfur fumigation on glycoside profile in Platycodonis Radix (Jiegeng)[J].Chin Med,2016,11(1):32
[37] JIN X,ZHU L Y,SHEN H,et al.Influence of sulphur-fumigation on the quality of white ginseng:a quantitative evaluation of major ginsenosides by high performance liquid chromatography[J].Food Chem,2012,135(3):1141
[38] ZHANG HM,LI SL,ZHANG H,et al.Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach[J].J Pharm Biomed Anal,2012,62(62):258
[39] DAI S,SHANG Z,WANG F,et al.Novelty application of multi-omics correlation in the discrimination of sulfur-fumigation and non-sulfur-fumigation Ophiopogonis Radix[J].Sci Rep,2017,7(1):9971
[40] YAN Y,ZHANG Q,FENG F.HPLC-TOF-MS and HPLC-MS/MS combined with multivariate analysis for the characterization and discrimination of phenolic profiles in nonfumigated and sulfur-fumigated rhubarb[J].J Sep Sci,2016,39(14):2667
[41] DUAN B,HUANG L,CHEN S.Study on the destructive effect to inherent quality of Fritillaria thunbergii Miq.(Zhebeimu) by sulfur-fumigated process using chromatographic fingerprinting analysis[J].Phytomedicine,2012,19(6):562
[42] 杨小艳,李敏,卢道会,等.不同干燥方法对半夏质量的影响[J].成都中医药大学学报,2013,36(3):18 YANG XY,LI M,LU DH,et al.Influence of different drying methods on quality of Pinellia ternate[J].J Chengdu Univ Tradit Chin Med,2013,36(3):18
[43] 张慧慧,黄永亮,吴纯洁,等.电位滴定法测定半夏硫熏前后琥珀酸的含量变化[J].临床合理用药杂志,2015,8(2B):95 ZHANG HH,HUANG YL,WU CJ,et al.The content of succinic acid was measured by potentiometric titration[J].Chin J Clin Rat Drug Use,2015,8(2B):95
[44] 王刚,晋小军,王辉,等.硫磺熏制与贮藏期对当归二氧化硫残留量的影响[J].时珍国医国药,2014,25(2):453 WANG G,JIN XJ,WANG H,et al.The influence of smoked and storage to angelica sulfur dioxide and quality residues[J].Lishizhen Med Mater Med Res,2014,25(2):453
[45] DUAN SM,XU J,BAI YJ,et al.Sulfur dioxide residue in sulfur-fumigated edible herbs:the fewer,the safer?[J].Food Chem,2016,192:119
[46] CAO G,LI Q,ZHANG J,et al.A purge and trap technique to capture volatile compounds combined with comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry to investigate the effect of sulfur-fumigation on Radix Angelicae Dahuricae[J].Biomed Chromatogr,2014,28(9):1167
[47] CAO G,LI Q,WU X,et al.Coupling needle-trap devices with comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry to rapidly reveal the chemical transformation of volatile components from sulfur-fumigated ginseng[J].J Sep Sci,2015,38(7):1248
[48] WEI WL,HUANG LF.Simultaneous determination of ferulic acid and phthalides of Angelica sinensis based on UPLC-Q-TOF/MS[J].Molecules,2015,20(3):4681
[49] AI YJ,XU JD,KONG M,et al.Discovery of characteristic chemical markers for inspecting sulfur-fumigated Radix Angelicae Sinensis by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry based metabolomics and chemical profiling approach[J].Food Res Int,2015,76(3):387
[50] YOSHIKAWA M,HATAKEYAMA S,TANIGUCHI K,et al.6-gingesulfonic acid,a new anti-ulcer principle,and gingerglycolipids A,B,and C,three new monoacyldigalactosylglycerols,from Zingiberis Rhizoma originating in Taiwan[J].Chem Pharm Bull,1992,40(8):2239
[51] WU CY,KONG M,ZHANG W,et al.Impact of sulphur fumigation on the chemistry of ginger[J].Food Chem,2018,239:953
[52] 郑玉忠,张振霞,张勇,等.硫熏山药对六味地黄丸中有效成分的影响[J].中国实验方剂学杂志,2015,21(18):48 ZHENG YZ,ZHANG ZX,ZHANG Y,et al.Effects of sulfur-fumigated Dioscoreae Rhizoma on active ingredients of Liuwei Dihuang Wan[J].Chin J Exp Tradit Med Form,2015,21(18):48
[53] 孔凤利,张浩,杜伟锋,等.硫磺熏蒸对浙贝母中贝母素甲和贝母素乙在大鼠体内药动学的影响[J].中草药,2017,48(13):2691 KONG FL,ZHANG H,DU WF,et al.Influence of sulfur-fumigation on pharmacokinetic of peimine and peiminine of Fritillaria thunbergii in rat[J].Chin Tradit Herb Drugs,2017,48(13):2691
[54] MA XQ,LEUNG AK,CHAN CL,et al.UHPLC UHD Q-TOF MS/MS analysis of the impact of sulfur fumigation on the chemical profile of Codonopsis Radix (Dangshen)[J].Analyst,2014,139(2):505
[55] LOU Y,CAI H,LIU X,et al.Element analysis and characteristic identification of non-fumigated and sulfur-fumigated Fritillaria thunbergii Miq.using microwave digestion-inductively coupled plasma atomic emission spectrometry combined with fourier transform infrared spectrometry[J].Pharmacogn Mag,2014,10(37):S30
[56] 汤坚,汪华君,蒋俊,等.基于主成分分析和硫熏前后无机元素含量变化的硫熏与非硫熏菊花鉴别方法[J].中国实验方剂学杂志,2014,20(13):97 TANG J,WANG HJ,JIANG J,et al.Identification method for sulphur fumigated Chrysanthemi Flos based on principal component analysis and element contents[J].Chin J Exp Tradit Med Form,2014,20(13):97
[57] 刘晓,马晓青,蔡皓,等.硫磺熏蒸前后中药金银花中金属元素及微量元素的ICP-AES检测[C]//中华中医药学会中药炮制分会2011年学术年会论文集.贵阳:2011 LIU X,MA XQ,CAI H,et al.Determination of metallic and trace elements in Lonicerae japonicae Flos before and after sulfur-fumigated process by ICP-AES[C]//Proceeding of 2011 Academic Annual Meeting of Chinese Traditional Medicine Processing Branch of Chinese Medical Association.Guiyang:2011
[58] 娄雅静,蔡皓,陈逸珺,等.微波消解-ICP-AES法分析测定当归与硫磺熏蒸当归中重金属、硫和微量元素[J].中国新药杂志,2013,22(6):719 LOU YJ,CAI H,CHEN YJ,et al.Analysis of heavy metals,sulfur and trace elements in sun-dried and sulfur-fumigated Angelicae Sinensis Radix by microwave digestion-ICP-AES method[J].Chin J New Drugs,2013,22(6):719
[59] 刘静静,蔡皓,刘晓,等.ICP-AES法分析硫磺熏蒸前后白芍中有害重金属、硫及主要微量元素的变化[J].中国中药杂志,2011,36(13):1790 LIU JJ,CAI H,LIU X,et al.Analysis of harmful heavy metals,sulfur and main trace elements from Paeoniae Radix Alba before and after sulfur-fumigated process by ICP-AES method[J].China J Chin Mater Med,2011,36(13):1790
[60] 李先端,胡世林,杨连菊.半夏不同加工品的微量元素分析[J].中国中药杂志,1991,16(5):279 LI XD,HU SL,YANG LJ.Analysis of trace elements in processed products of Pinellia ternata (Thunb.) Breit[J].China J Chin Mater Med,1991,16(5):279
[61] 李友连.硫磺熏蒸对菊花化学成分、吸收及代谢影响研究[D].合肥:安徽中医药大学,2016 LI YL.The Research on the Chemical Constituents,Absorption and Metabolism of Chrysanthemum Flos Processed by Sulfur Fumigation[D].Hefei:Anhui University of Chinese Medicine,2016
[62] ZHU H,SHEN H,XU J,et al.Comparative study on intestinal metabolism and absorption in vivo of ginsenosides in sulphur-fumigated and non-fumigated ginseng by ultra performance liquid chromatography quadruple time-of-flight mass spectrometry based chemical profiling approach[J].Drug Test Anal,2015,7(4):320
[63] MA B,KAN WL,ZHU H,et al.Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng[J].J Ethnopharmacol,2017,195:222
[64] 马逾英,高颖,邹文莉,等.熏硫川白芷药材对小鼠镇痛作用的影响[J].华西药学杂志,2006,21(6):616 MA YY,GAO Y,ZOU WL,et al.Analgesic effect of sulfured Cuan Baizhi on mice[J].West China J Pharm Sci,2006,21(6):616
[65] 吴晓毅,巢志茂,王梦缘,等.硫磺熏蒸对白芷中欧前胡素含量的影响[J].中国中医药信息杂志,2014,21(8):85 WU XY,CHAO ZM,WANG MY,et al.Effects of sulphur fumigation on content of imperatorin in Angelicae Dahuricae Radix (Baizhi)[J].Chin J Inf Tradit Chin Med,2014,21(8):85
[66] KONG M,LIU HH,WU J,et al.Effects of sulfur-fumigation on the pharmacokinetics,metabolites and analgesic activity of Radix Paeoniae Alba[J].J Ethnopharmacol,2017,212:95
[67] ZHAN JY,YAO P,BI CW,et al.The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix[J].Phytomedicine,2014,21(11):1318
[68] 刘成松,王玉萍,史彦斌,等.硫磺熏蒸党参对小鼠免疫功能的影响[J].中药材,2014,37(11):1969 LIU CS,WANG YP,SHI YB,et al.Effect of Codonopsis Radix maintained with sulfur fumigation on immune function in mice[J].J Chin Med Mater,2014,37(11):1969
[69] 郭婕,赵海霞,颜燕,等.硫磺熏蒸山药对大鼠肝组织抗氧化能力及ATP酶活性的影响[J].中国实验方剂学杂志,2010,16(11):150 GUO J,ZHAO HX,YAN Y,et al.Effect of sulfur fumigated dioscorea opposita on oxidative stress and ATP enzyme in liver of rats[J].Chin J Exp Tradit Med Form,2010,16(11):150
[70] 丁喜炎,季琳,程雪,等.不同硫熏替代技术的黄芪药材对小鼠免疫功能影响研究[J].中国中药杂志,2016,41(15):2819 DING XY,JI L,CHENG X,et al.Effect of Astragali Radix with different sulfur fumigation technologies on immune function in mice[J].China J Chin Mater Med,2016,41(15):2819
[71] JIANG D,CHEN Y,HOU X,et al.Influence of Paeonia lactiflora roots extract on cAMP-phosphodiesterase activity and related anti-inflammatory action[J].J Ethnopharmacol,2011,137(1):914
[72] 王巧.芍药质量控制方法与白芍总苷药物动力学研究[D].沈阳:沈阳药科大学,2005 WANG Q.Studies on the Method of Quality Control of Paeony Root and Pharmacokinetic of Total Glucoside of Paeony[D].Shenyang:Shenyang Pharmaceutical University,2005
[73] 黄山君,王瑞,石燕红,等.硫磺熏制白芍的安全性评价初步研究[J].药学学报,2012,47(4):486 HUANG SJ,WANG R,SHI YH,et al.Primary safety evaluation of sulfated Paeoniae Radix Alba[J].Acta Pharm Sin,2012,47(4):486
[74] 付联强,魏香兰.芍药苷和芍药苷亚硫酸酯代谢产物的比较[J].中国医院药学杂志,2014,34(19):1656 FU LQ,WEI XL.Comparative study of paeoniflorin and paeoniflorin sulfite metabolites[J].Chin J Hosp Pharm,2014,34(19):1656
[75] CHENG Y,PENG C,WEN F,et al.Pharmacokinetic comparisons of typical constituents in white peony root and sulfur fumigated white peony root after oral administration to mice[J].J Ethnopharmacol,2010,129(2):167
[76] PEI K,CAI H,LIU X,et al.Evaluation of the influence of sulfur fumigation on the pharmacokinetics of four active ingredients in Siwu Tang[J].J Sep Sci,2015,38(1):25
