中药珍珠层粉X射线衍射指纹图谱研究

目的：建立中药珍珠层粉X射线衍射指纹图谱，为珍珠层粉质量评价提供新的方法。方法：采用X射线衍射技术对珍珠层粉进行定性分析，并对21批不同基原和产地的珍珠层粉进行评价。结果：得到了21批珍珠层粉的X射线衍射图谱，其中18批样品的衍射图谱几何拓扑特征基本一致，利用这18批珍珠层粉的X射线衍射图谱，建立中药珍珠层粉的X射线衍射指纹图谱，并建立其对照图谱，经过寻峰处理得到共有峰，以夹角余弦法和相关系数法计算18批珍珠层粉X射线衍射图谱的相似度，发现不同样品X射线衍射图谱具有较高的相似度，而劣质珍珠层粉的X射线衍射图谱与正品存在显著差别。结论：X射线衍射指纹图谱分析方法专属性强，准确可靠，可实现对中药珍珠层粉的鉴别和质量评价。

Objective:To establish the fingerprint of pearl stratum powder to provide a new method for evaluating the quality of pearl stratum powder. Methods:Qualitative analysis of pearl stratum powder was carried out by X-ray diffraction technology, and samples from different origins and habitats were evaluated. Results:Twenty-one samples of pearl stratum powder were X-ray diffracted. The geometrical and topological characteristics of eighteen samples were similar. The X-ray diffraction fingerprint and contrast map of pearl stratum powder were established. According to the intensity of characteristic peaks in the X-ray diffraction pattern of pearl stratum powder, the similarity of different samples was calculated by cosine law and correlation coefficient method. pattern of pearl stratum powder, the similarities of different samples were calculated by cosine law and correlation coefficient method. After similarity calculation, the results showed that similarities of different samples were high. The X-ray diffraction patterns of inferior products were significantly different from those of genuine products. Conclusion:The X-ray diffraction fingerprint is specific and accurate, and can be used to evaluate pearl stratum powder.

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