全国中药资源普查女贞子药材质量现状研究

目的：了解全国范围内女贞子的质量现状，为完善女贞子的质量控制和安全性评价标准提供依据。方法：依据《中华人民共和国药典》（2015年版）女贞子项下含量测定方法，测定全国第4次中药资源普查所收集的不同产地的48批女贞子样品中特女贞苷含量，应用ICP-MS法测定其21个无机元素的含量，并测定样品的百粒重。结果：4批样品（S2、S23、S29、S47）特女贞苷含量未达到《中华人民共和国药典》（2015年版）项下要求，其百粒重均小于1.80 g，而其他44批样品百粒重均大于等于1.80 g，说明百粒重与样品特女贞苷含量具有相关性，可作为初步评价女贞子质量的方法。4批样品（S3、S36、S15和S30）的有害元素及重金属元素限量超出《药用植物及制剂进出口绿色行业标准》的限量要求，其可能与药材原植物生长基地的土壤、水源等因素有关。结论：全国不同产地的48批女贞子样品整体质量势态较优，本实验数据可为完善女贞子的质量控制及安全性评价提供依据。

Objective: To provide the basis for improving its quality control and safety evaluation standard by understanding the quality status of Ligustri Lucidi fructus in China. Methods: 48 batches of Ligustri Lucidi Fructus samples were collected by the fourth national survey of traditional Chinese medicine resources, whose specnuezhenide conents were determined by the method of the Chinese Pharmacopoeia(2015 Edition). The contents of 21 inorganic elements were determined by ICP-MS, and the 100-grain weights of the samples were determined. Results: Four batches of samples(S2, S23, S29, S47) did not meet the requirements of specnuezhenide of the Chinese Pharmacopoeia (2015 Edition),with 100-grain weights less than 1.80 g. And the other 44 batches of samples were all more than 1.80 g in weight. The results showed that the 100-grain weight was related with the content of specnuezhenide,which could be used as a preliminary method to evaluate the quality of Ligustrum lucidum. The content of harmful elements and heavy metals in four batches of samples (S3, S36, S15 and S30) exceeded the limits of the Green Trade Standard for Import and Export of Medicinal Plants and Preparations,which might be related with the soil and water source of the growth base of the original plant. Conclusion: The overall quality situation of 48 samples from different habitants in China was satisfactory. The experimental data can provide the basis for improving the quality control and safety evaluation of Ligustri Lucidi fructus.

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