CYP2C19基因多态性对侵袭性真菌感染患者伏立康唑游离型药物浓度的影响

目的：考察CYP2C19基因多态性对侵袭性真菌感染患者伏立康唑游离型药物浓度的影响。方法：收集三峡中心医院使用伏立康唑进行治疗的患者的血液标本，进行CYP2C19基因型检测和伏立康唑游离型药物浓度测定，分析CYP2C19基因3种亚型对伏立康唑游离型药物浓度的影响。结果：78例患者的伏立康唑平均游离型药物浓度为（2.33&#177;1.09）mg&#183;mL^-1，3组CYP2C19基因亚型患者伏立康唑游离型药物浓度有显著差异（P<0.01），组间多重比较显示，3组cyp2c19基因亚型患者伏立康唑游离型浓度为em型

Objective: To analyze the influence of CYP2C19 gene polymorphism on unbound plasma concentration of voriconazole in patients with invasive fungal infections (IFIs). Methods: Blood samples were collected from patients with IFIs, who treated with voriconazole in our hospital, and detected the CYP2C19 gene polymorphism and unbound plasma concentrations(C_u) of voriconazole. Results: 78 patients were enrolled, the average voriconzole C_u was (2.33&#177;1.09) mg&#183;mL^-1. Significant difference was found among the three CYP2C19 subtypes (P<0.01), Multivariate analysis revealed that, EM<IM<PM in C_u of voriconazole(P<0.01). Conclusion: CYP2C19 gene polymorphism influence C_u of voriconazole significantly.

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