您当前的位置：首页 >> 正文

栀子与西红花中西红花苷纯化、分析及构效关系研究进展

Research progress of purification,determination and structure-activity relationship of crocins from gardenia and saffron

作者(英文)：

单位：1. 遵义医学院珠海校区珠海市中药基础及应用研究重点实验室, 珠海 519041;2. 四川大学华西药学院生药学教研室, 成都 610041;3. 昆明医科大学药学院暨云南省天然药物药理重点实验室, 昆明 650500

单位(英文)：1. Zunyi Medical College Zhuhai Campus, Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai 519041, China;
2. Department of Pharmacognosy, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;
3. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China

关键词：crocins; gardenia; saffron; separation; purification; determination; structure-activity relationship

关键词(英文)：crocins; gardenia; saffron; separation; purification; determination; structure-activity relationship

分类号：R917

出版年·卷·期（页码）：2018,38 (5):735-747

DOI: 10.16155/j.0254-1793.2017.01.01

-----摘要：-------------------------------------------------------------------------------------------

西红花苷为自然界存在的唯一水溶性类胡萝卜素，主要包括西红花苷-1、西红花苷-2、西红花苷-3、西红花苷-4和顺式西红花苷-1。与其他广泛分布于多种植物的各类天然产物不同，西红花苷仅来源于中药西红花和栀子，在这2味中药中含量较高，并具有广泛药理活性。因此，为更深入研究西红花苷类成分药用价值，对这类成分的分离纯化、分析测定及构效关系进行深入研究尤为重要。本文综合近30年来相关文献报道，从西红花苷分离纯化、分析测定及构效关系3个方面进行概述并汇总相关文献，为西红花苷深入研究及开发利用提供参考依据。

-----英文摘要：---------------------------------------------------------------------------------------

Crocins are the only water-soluble carotenoids in nature,and consist of crocin-1,crocin-2,crocin-3,crocin-4 and cis-crocin-1.Unlike other chemicals widely distributed in various natural herbal remedies,crocins are exclusively contained in traditional Chinese medicines including gardenia and saffron with high content.These carotenoids have extensive pharmacological activities.Therefore,in order to further study the medicinal value of crocins,it is crucial to investigate the separation,purification,determination and structure-activity relationship of crocins.Current review summarizes the separation,purification,determination and structure-activity relationship of crocins based on the references of the past 30 years,and therefore facilitates further research and development of crocins.

-----参考文献：---------------------------------------------------------------------------------------

栀子与西红花中西红花苷纯化、分析及构效关系研究进展

Research progress of purification,determination and structure-activity relationship of crocins from gardenia and saffron

欢迎阅读《药物分析杂志》！您是该文第 1229位读者！