Objective: To study stability of deslanoside injection. Methods: The stability of deslanoside injection was investigated through acid destruction,alkaline destruction,oxidative destruction,light destruction,high-temperature processing at 121 ℃,accelerated test,and long-term test.Change trends of main content and impurity content of deslanoside injection were determined by HPLC.The Agilent ZORBAX-SB C18 column was used with gradient elution,taking acetonitrile-methanol (232:148) as mobile phase A and water as mobile phase B.The flow rate was 1.0 mL·min-1.The wavelength of detector was 220 nm. Results: Deslanoside injection was unstable under conditions of acid destruction,alkaline destruction,oxidative destruction,and light destruction,high-temperature processing at 121 ℃,the content of its impurities obviously increased under all of these conditions.In accelerated test,after being stored for 0,1,2,3,and 6 months,the average main content of 3 batches of deslanoside injection declined to 99%,97%,95%,92%,88%.In long-term test,after being stored for 0,3,6,9,12,18,24 months,the average main content of 3 batches of deslanoside injection declined to 99%,98%,97%,96%,94%,92%,89%. Conclusion: Sterilization temperature and time should be well controlled for deslanoside injection which should be tightly closed and kept out of light at a low temperature.Besides,rational expiration date should be specified for deslanoside injection.
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