药用胶囊中铬元素的LIBS快速检测

目的：建立LIBS技术快速检测药用胶囊中Cr元素的方法。方法：本文利用脉冲激光聚焦后作用于胶囊表面产生等离子体，通过光纤光谱仪采集并分析等离子体发射光谱即可得到胶囊中元素信息。结果：LIBS技术无需对胶囊进行处理即可快速分析胶囊成分，对于Cr原子，最佳分析谱线为357.34 nm。实验检测了19种胶囊制剂，11种样品检测到Cr谱线。其中1种样品利用原子吸收法检测Cr含量为7 mg·kg^-1，由此推算LIBS检测胶囊制剂中Cr元素含量检测限可至1 mg·kg^-1以下。结论：利用LIBS技术可实现数十秒钟快速检测药用胶囊中Cr含量是否超标。

Objective: To establish a method for rapid detection of chromium in medicinal capsules by LIBS technology. Methods: One laser beam was used for ablation capsules to produce plasma and elements on the capsule surface to be identified through the plasma spectra using a spectrometer. Results: The elements in capsules were analyzed rapidly by LIBS technology without sample preparation and 357.34 nm line was an optimal choice for chromium element analysis.In the experiment,19 kinds of capsules were analyzed and Cr lines were found in 11 samples.Chromium content in one kind sample was 7 mg·kg^-1 measured by atomic absorption. Conclusion: LIBS analysis technology is well suited for rapid determination of chromium content in capsules.

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