阿昔洛韦2/3水合物的制备和表征

目的: 建立阿昔洛韦2/3水合物的制备方法和完整的晶型表征分析方法。 方法: 在水中重结晶制备阿昔洛韦2/3水合物,并采用衰减全反射红外和红外吸收光谱、差示扫描量热分析、热重分析、粉末和单晶X-射线衍射法对该晶型进行全面的表征。 结果: 获得了阿昔洛韦2/3水合物晶型制备和表征方法,得到了傅立叶衰减全反射红外光谱和热重分析谱图,通过热分析法探明了阿昔洛韦2/3水合物向无水晶型转化和无水晶型间转化的过程及其对应的热效应,5.18%的失重率对应于2/3结晶水。 结论: 所建立的晶型制备方法简便,阿昔洛韦2/3水合物晶型表征方法可靠,数据全面。

Objective: To establish the methods for preparation and characterization of acyclovir 2/3 hydrate. Methods: Acyclovir 2/3 hydrate was obtained by re-crystallization using water as the solvent and was comprehensively characterized by infrared spectroscopy,differential scanning calorimetry(DSC),thermogravimetry analysis(TGA),and X-ray diffraction. Results: The preparation and characterization method for the crystal form of acyclovir 2/3 hydrate was achieved.The attenuated total reflectance fourier transform infrared spectrum(ATR-FT-IR) and the TGA spectrum were reported for the first time.In thermal analysis,the thermal events of transformation from hydrate to anhydrous form were demonstrated and the weight loss of 5.18% observed in the TGA curve was equivalent to the stoichiometric water content in acyclovir 2/3 hydrate. Conclusion: The established crystal preparation method is simple,and the characterization method for the acyclovir 2/3 hydrate crystal is reliable with sufficient data.