奥硝唑氯化钠注射液主要杂质的结构鉴定
Characterization of major impurity in ornidazole and sodium chloride injection
分类号：
出版年·卷·期（页码）：2012,32 (10):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的: 对奥硝唑氯化钠注射液的主要杂质进行结构分析。 方法: 采用HPLC-QTOF-MS联用技术对该杂质进行鉴定;利用制备高效液相色谱从奥硝唑氯化钠注射液中分离制备该杂质,并进一步采用核磁技术进行结构确证。 结果: 确证了奥硝唑氯化钠注射液的1个主要杂质的结构。 结论: 本研究对奥硝唑氯化钠注射液的杂质分析、质量控制具有重要作用。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To identify the structure of the major impurity of ornidazole and sodium chloride injection. Methods: HPLC-QTOF-MS was adopted to analyze the structure of this impurity;the impurity was separated from ornidazole and sodium chloride injection by prep-HPLC,and its structure was further identified by NMR. Results: The chemical structure of the major impurity of ornidazole and sodium chloride injection was elucidated. Conclusion: The study offers scientific data for studying the impurities of ornidazole and sodium chloride injection and improving its quality.
-----参考文献：---------------------------------------------------------------------------------------
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