自身对照法测定复方黄连素片溶出度

目的: 建立自身对照法测定复方黄连素片溶出度。 方法: 采用自身对照法(UV)测定复方黄连素片的溶出度。采用篮法,溶出介质为纯化水(900 mL),转速100 r·min^-1,取样时间90 min。 结果: 复方黄连素片溶出度测定自身对照法在1.2~9.0 μg·mL^-1 浓度范围内呈线性(r=0.9995,n=5),回收率98.9%,RSD=0.03%。 结论: 本法简便、准确、可行,可作为复方黄连素片的质量标准中控制项目之一。

Objective: To establish a self-control method for determination the dissolution of the compound huangliansu tablets. Methods: The UV spectrophotometry method was applied to determine the dissolution of the compound huangliansu tablets.Basket apparatus was used with water as the dissolution medium at a speed of 100 r·min^-1 and dissolution time limit was 90 min. Results: The linear range of the compound huangliansu tablets was 1.2-9.0 μg·mL^-1 and the correlation coefficient was 0.9995.The average recovery was 98.90%,and the RSD was 0.03%. Conclusion: The method is convenient,accurate and practicable.It can be applied to determine the dissolution of the tablets.

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