阿司匹林包合物的拉曼光谱和红外光谱研究

目的: 通过拉曼光谱和红外光谱法分析阿司匹林包合物,探索拉曼光谱法作为一种新的验证包合物形成方法的可行性。 方法: 通过共聚焦拉曼光谱仪和傅里叶红外光谱仪分别测定并获得β-环糊精、阿司匹林、β-环糊精和阿司匹林物理混合物、阿司匹林包合物的拉曼图谱和红外图谱并将其进行对照分析。 结果: 在红外图谱和拉曼图谱中,阿司匹林的一些特征峰在其包合物中发生了位移,部分峰强发生变化甚至消失。 结论: 拉曼光谱和红外光谱同时表明,阿司匹林通过氢键作用嵌入β-环糊精的疏水空腔形成了包合物,其苯环结构、羰基结构和酯基结构被包裹于β-环糊精的空腔结构中。

Objective: To identify the formation of the inclusion compound of aspirin by the confocal Raman spectroscopy and infrared spectroscopy in order to decide the ability of the Raman spectroscopy as a new and simple method in identifying the inclusion compound. Methods: To obtain the Raman spectrum and infrared spectrum of aspirin,β-cyclodextrin,β-cyclodextrin and aspirin physcal mixture,aspirin-beta-cyclodextrin inclusion compound in the solid state with confocal Raman spectrometer and Fourier transform infrared spectrometer,and then was compared with each other and to reveal the structural features. Results: Marker bands of aspirin were shifted or weakened,ever dispeared in both IR and Raman spectrums. Conclusion: IR and Raman spectrum both indicated that the aspirin inclusion compound is formed via hydrogen bonds,and benzene ring,carbonyl group and ester group were included in the cavity of β-CD.

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