吴茱萸碱和吴茱萸次碱电喷雾-离子阱质谱裂解途径研究
ESI-ion-trap MS study on fragmentation pathways of evodiamine and rutecarpine
分类号：
出版年·卷·期（页码）：2012,32 (5):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的: 对吴茱萸碱和吴茱萸次碱的电喷雾质谱裂解机制进行研究。 方法: 在电喷雾离子源,正、负离子模式下,分析吴茱萸碱和吴茱萸次碱的一级和多级质谱图。 结果: 解析了吴茱萸碱和吴茱萸次碱多级质谱碎片,在正负离子模式下,主要发生Rretro-Diels-Alder(RDA)裂解。 结论: 吴茱萸碱和吴茱萸次碱的ESI-MS质谱裂解途径可为吲哚类生物碱的成分研究提供数据参考。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To study the fragmentation pathways of evodiamine and rutecarpine by electrospray ionization mass spectrometry(ESI-MSn). Methods: Evodiamine and rutecarpine were analyzed using ESI-MSn in positive and negative ion mode.The first and multi-stage mass spectrum diagrams of evodiamine and rutecarpine were obtained. Results: Under positive or negative mode,Rretro-Diels-Alder(RDA)decomposition occurs mainly. Conclusion: The results provides the basis data for the chemical constituents studying of volatile or indole quinazoline alkaloid.
-----参考文献：---------------------------------------------------------------------------------------
1 ChP(中国药典).2010.Vol Ⅰ(一部):160
2 TENG Jie(滕杰),YANG Xiu-wei(杨秀伟).Analysis of vola tile oil components in Evodiae Fructus from various habitats(不同产地吴茱萸挥发油气相色谱-质谱联用分析).Mod Chin Med(中国现代中药),2009,11(11):17
3 LOU Fang-ming(娄方明),LI Qun-fang(李群芳),HUANG Xie-nan(黄燮南),et al.Analysis of the essential oil from Evodia rutaecarpa(Juss.)Benth.by SPME-GC-MS(固相微萃取-气相色谱-质谱联用分析吴茱萸挥发油成分分析).Chin J Pharm Anal(药物分析杂志),2010,30(7):1248
4 Teng J,Yang XW.A new limonoid from the fruits of Evoida rutaecarpa(Juss.)Benth..Pharmazie,2006,61(12):1038
5 Zhao Meng-yao,Yang Xiu-wei.Optimization of the extraction conditions and simultaneous quantification by RP-LC of six alkaloids in Evodiae Fructus.Chromatographia,2008,67(7-8):543
6 QIU Guo-li(裘国丽),LUAN Lian-jun(栾连军),CHENG Yi-yu(程翼宇).Simultaneous determination of evodiamine and rutaecarpine in rabbit plasma by HPLC-MS(液相色谱-电喷雾质谱法测定血浆中吴茱萸碱和吴茱萸次碱浓度).Chin J Pharm Anal(药物分析杂志),2005,25(10):1179
7 LUAN Lian-jun(栾连军),QIU Guo-li(裘国丽),CHENG Yi-yu(程翼宇).Study on pharmacokinetics of evodiamine and rutaecarpine in rabbit(吴茱萸碱和吴茱萸次碱在家兔体内的药动学研究).Acta Pharm Sin(药学学报),2006,41(1):48
8 ZHANG Xue-qin(张雪琴),ZHOU Xin(周欣),WANG Dao-ping(王道平),et al.Analysis of alkaloids in Evodia rutaecarpa from different habitats by liquid chromatography/mass spectrometry(液相色谱-质谱联用研究不同产地吴茱萸中生物碱成分).Chin J Anal Chem(分析化学),2005,33(2):241
9 LIAO Qiong-feng(廖琼峰),XIE Zhi-yong(谢智勇),ZHANG Lei(张蕾),et al.Mass spectrometric analysis of quinazoline alkaloid and limonin from Fructus Evodiae(吴茱萸中吲哚喹唑啉类生物碱和吴茱萸内酯质谱裂解分析).J Chin Med Mater(中药材),2008,31(5):673
欢迎阅读《药物分析杂志》！您是该文第 1088位读者！
