核磁共振技术在药品标准领域中的应用进展

本文介绍了核磁共振分析技术的原理、定性分析方法、定量分析方法。综述了核磁共振分析技术在美国药典、欧洲药典、日本药局方和中国药典中的应用现状,并对其应用前景进行了展望。

The principles of nuclear magnetic resonance,quantitative and qualitative analytical methods are introduced.The applications of nuclear magnetic resonance in United States Pharmacopeia,European Pharmacopoeia,Japanese Pharmacopoeia and Chinese Pharmacopoeia are mentioned,also is the potential application in future.

[1] Bloch,F.Nuclear induction.Phys Rev,1946,70:460
[2] Purcell EM,Torrey EC,Pound RV.Resonance absorption by nuclear magnetic moments in a solid.Phys.Rev.1946,69:37
[3] Ernst RR,Anderson WA. Rev Sci Instrum, 1966,37:93
[4] Wuthrich K,Shulman RG,Yamane T,et al.High resolution proton magnetic resonance studies of cyanoferrimyoglobins and alkylated derivatives from different species.J Biol Chem,1970,245:1947
[5] Lauterbach SR,Cambria RP,Brewster DC,et al.Contemporary management of aortic branch compromise resulting from acute aortic dissection.J Vasc Surg.2001,33:1185
[6] Filler,AG.The history,development,and impact of computed imaging in neurological diagnosis and neurosurgery:CT,MRI,DTI.Nature Precedings.doi:10.1038/npre.2009.3267.2
[7] Pellecchia M,Sem DS,Wuthrich K.NMR in drug discovery.Nat Rev Drug Discov.2002,1:211
[8] Salvatella X,Giralt E.NMR-based methods and strategies for drug discovery. Chem Soc Rev,2003,32:365
[9] Congreve M,Murray CW,Blundell T L.Structural biology and drug discovery.Drug Discov Today,2005,10:895
[10] Wishart D.NMR spectroscopy and protein structure determination:applications to drug discovery and development.Curr Pharm Biotechnol,2005,6:105
[11] Oldfield E.Chemical shifts in amino acids,peptides,and proteins:from quantum chemistry to drug design.Annu Rev Phys Chem,2002,53:349
[12] USP.33:761
[13] EP.7.1:2.2.33
[14] BP.2011:2.2.33
[15] JP.15:2.21,p38
[16] ChP(中国药典).2010.Vol Ⅱ (二部):Appendix(附录) IX K
[17] ChP(中国药典).2010.Vol Ⅱ(二部):1208