振动光谱法研究灯盏花素固体分散体的分散特性

目的: 用拉曼和红外光谱法研究灯盏花素固体分散体的分散性, 以期获得一种新的简单易行的检查固体分散体分散性的方法。 方法: 用溶剂法制备灯盏花素固体分散体, 用显微共焦拉曼光谱仪、傅里叶变换红外光谱仪和X射线衍射仪分别采集灯盏花素、乙基纤维素(EC)、灯盏花素:EC(1∶ 3)的物理混合物(PM)以及灯盏花素固体分散体(SD_bre)的拉曼图谱、红外图谱和X射线衍射图谱并进行对比分析。 结果: 灯盏花素以分子状态包埋在EC的网状骨架中, 三种方法得到一致的结果。 结论: 拉曼光谱法快速、直接、对样品无损伤, 是一种新的理想的检查固体分散体分散性的方法。

Objective: To study the dispersivity of breviscapine solid dispersion by Raman spectrometry and infrared spectrometry in order to obtain a new and simple method in examining the dispersivity of solid dispersion. Methods: Breviscapine solid dispersion was prepared by solvent method.The Raman spectra,infrared spectra and XRD spectra of breviscapine,ethyl cellulose(EC),physical mixture,solid dispersion were acquired by Raman and Fourier transform infrared spectrometers and X-ray powder diffractometry.And the spectra were compared with each other in or der to find out the differences between breviscapine solid dispersion and other materials. Results: The three methods obtained the same result-breviscapine was dispersed in the reticular framework of EC in the state of molecule. Conclusions: Raman spectrometry which is fast,direct and non-destructive is an ideal method in examining the dispersivity of solid dispersion.