奥硝唑在碳纳米管修饰的玻碳电极上的电化学行为及分析应用

目的: 研究奥硝唑在碳纳米管修饰的玻碳电极上的电化学行为及其测定方法。 方法: 循环伏安法和线性扫描伏安法。 结果: 在0.2 mol.L^-1 NH₃-NH₄Cl缓冲溶液(pH 9.0)和1.2 mol·L^-1 NaCl溶液组成的底液中,奥硝唑在-0.62 V(υs.SCE)处出现一灵敏的还原峰,2.0×10^-7~3.0×10^-5 mol·L^-1范围内呈线性关系 (r=0.998),检出限为1.5×10^-8 mol·L^-1。并用循环伏安法研究了奥硝唑还原峰的电流性质,发现电极反应是完全不可逆的,并存在一定的吸附性。 结论: 利用奥硝唑在碳纳米管修饰的玻碳电极上的还原行为建立的分析方法简便灵敏,结果准确可靠,可用于奥硝唑的质量监控及药代动力学研究。

Objective: The electrochemical behavior and determination of ornidazole using a multi-wall carbon nanotube modified glassy carbon electrode have beenn studied. Methods: Cyclic voltammetry and linear sweep voltammetry. Results: The results showed that asensitive reduction peak of ornidazole was obtained in the base solution of NH₃-NH₄Cl buffer solution(pH 9.0) and 1.2 mol·L^-1NaCl solution.The peak potential was-0.62 V(υs.SCE).The peak current was directly proportional to the ornidazole concentration in the rang of 2.0×10^-7-3.0×10^-5 mol·L^-1(r=0.998).The detection limit was 1.5×10^-8 mol·L^-1.The current property of reduction peak of ornidazole was investigated by the cyclic voltammetry.The characteristic irreversible adsorption of the peak was proved. Conclusion: The reduction behavior of ornidazole was investigated.This method is simple,sensitive,accurate and can be used for the determination and pharmacokinetics study of ornidazole.