苹果酸舒尼替尼脂质体药物含量及包封率的测定
Determination of content and entrapment efficiency of sunitinib malate liposome
分类号：
出版年·卷·期（页码）：2011,31 (7):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的: 建立苹果酸舒尼替尼脂质体含量及包封率的测定方法。方法: 采用可见分光光度法测定苹果酸舒尼替尼的含量。阳离子交换树脂法分离游离药物,分光光度法测定脂质体中苹果酸舒尼替尼的包封率。结果: 苹果酸舒尼替尼在430 nm处有最大吸收,4.0 ~ 15.0 μg·mL-1范围内线性关系良好(r=0.9998,n=7);苹果酸舒尼替尼脂质体的平均包封率为91.89%。结论: 所用方法简便、准确,可用于苹果酸舒尼替尼脂质体的含量及包封率测定。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To develop a method for the determination of content and entrapment efficiency of sunitinib malate(SU)loaded liposome. Methods: The determination of SU was performed by VIS; The entrapment efficiciency of SU liposomes was determined by VIS after separation of free SU from liposome with ion exchange ions. Results: The solution of SU was absorbed max at 430 nm wavelength.The linear range of SU was 4.0-15.0 μg·mL-1(r=0.9998,n=7).The average entrapment efficiency of SU liposomes was 91.89%. Conclusion: The method is acuurate and can be used to determine the content and entrapment efficience of SU loaded liposome.
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