紫外-可见分光光度法测定盐酸雷尼替丁胶囊含量的不确定度评定

目的: 建立紫外-可见分光光度法测定盐酸雷尼替丁胶囊含量的不确定度评定方法; 方法: 根据测量过程,全面鉴别不确定度来源,计算各分量的不确定度,建立数学模型,最后计算出合成标准不确定度u_c和扩展不确定度U₉₅. 结果: 盐酸雷尼替丁胶囊含量测定的结果可表示为98.6%±1.0%(k=2),合成标准不确定度u_c为0.5%和扩展不确定度U₉₅为1.0%; 结论: 本方法适用于紫外-可见分光光度法含量测定的不确定度评定,对合理地赋予被测定结果的分散性具有重要意义。

Objective: To establish a method for the evaluation of the uncertainty in the content determination of ranitidine hydrochloride capsules by UV. Method: According to the measurement process,Each components of uncertainty was calculated by analyzing the various variable sources of uncertainty generally,and a mathematical medel was established,The combined standard uncertainty u_c and the expanded uncertainty U₉₅ were then binally obtained. Result: The expression of the results of the content determination of ranitidine hydrochloride capsules was 98.6%±1.0%(k=2),the combined standard uncertainty u_c was 0.5%,the expanded uncertainty U₉₅ was 1.0%. Conclusion: This method is suitable for evaluating of the content determination by UV,and it is important meaning to give the dispersion of the determined results.