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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nifdc.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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超高效液相色谱法测定榄香烯脂质体的含量及包封率___

Determination of Content and Entrapment Efficiency of Elemene Liposomes with UPLC Method

作者: 曾昭武; 
单位:杭州师范大学 
关键词(英文):Elemene; Liposome; UPLC
分类号:
出版年·卷·期(页码):2010,30 (3):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:测定榄香烯脂质体的药物含量及包封率。方法:采用超高效液相色谱法(UPLC)检测榄香烯含量及包封率。结果:色谱条件下榄香烯与辅料、溶剂峰分离良好,β-榄香烯在1~100 μg·mL-1范围内线性关系良好。榄香烯脂质体平均包封率为(99.8±0.4)%。结论:超高效液相色谱法可用于检测榄香烯脂质体的含量和包封率,简单、快速且准确。

-----英文摘要:---------------------------------------------------------------------------------------

Objective To determine of content and entrapment efficiency of Elemene liposomes. Methods The content and entrapment efficiency of Elemene liposomes were determined by Ultra Performance Liquid Chromatography (UPLC). Results Elemene had a good linear relation in a range of 1-100 μg·mL-1. The average entrapment efficiency of Elemene liposomes reached (99.8±0.4)%. Conclusion UPLC method for determination of content and entrapment efficiency of Elemene liposomes was simple, fast and accurate.

-----参考文献:---------------------------------------------------------------------------------------

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3YAO Shu-juan(姚淑娟),LIU Bai-yang(刘伯阳),LV Li-yan(吕丽艳).Studies of reducing poison and increasing effect of elemene emulsions on immune function of tumor-bearing mice after chemiotherapy(榄香烯提高肿瘤化疗药物疗效及抗免疫抑制作用的研究).Chin Arch Trad Chin Med (中医药学刊), 2006,24(3):456
4SONG Xiao-dan(宋笑丹),WANG Xue-jun(王学军),DU Xia(杜霞),et al.HPLC determination of the content and entrapment efficiency of β-elemene liposome(HPLC法测定β-榄香烯脂质体药物含量及包封率).Chin J Pharm.Anal(药物分析杂志),2007,27(8).1222
5CAO Yue(曹悦),ZUO Dai-ying(左代英),WU Xiao-lan(吴晓兰), et al.Determination of swertiamarin and gentiopicroside in root of Gentiana scabra Bge.by UPLC(超高效液相色谱法测定龙胆药材中的獐芽菜苦苷和龙胆苦苷).Lishizhen Med Mater Med Res(时珍国医国药),2009,20(5):1079
6LIU Mei(刘梅),HAO Gui-xin(侴桂新),ZHANG Mian(张勉), et al.Determination of content of salvianolic acid B and tanshinoneⅡA with UPLC(超高效液相色谱法同时测定丹参药材中丹酚酸B和丹参酮ⅡA的含量).China J Chin Mater Med(中国中药杂志),2008,33(3):319
7LI Qing-wu(李庆武).The experimental study on β-elemene liposomes preparation and its device development(β-榄香烯脂质体的制备工艺研究与生产设备开发).Master degree thesis of Tianjin University(天津大学硕士学位论文),2005.23

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