RP-HPLC法测定盐酸甲氧氯普胺注射液含量及有关物质___
RP-HPLC determination of metoclopramide hydrochloride injection and its related substance
分类号：
出版年·卷·期（页码）：2010,30 (1):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
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-----英文摘要：---------------------------------------------------------------------------------------
Objective:To establish RP-HPLC method for determination of metoclopramide hydrochloride injection.Methods: Diamonsial C18 column(150 mm×4.6 mm,5 μm) was adopted with the mobile phase of acetonitrile-0.025 mol·L-1 ammonium acetate(including 0.2% triethylamine,adjusted to pH 5.7 with glacial acetic acid)(20∶80) at a flow rate of 1.0 mL·min-1;The detection wavelength was 275 nm and the column temperature was 30 ℃.Results:The calibration curve was linear in the range of 10-300 μg·mL-1(r=0.9997),and the limit of detection was 1 ng.Conclusion:The method is simple,accurate and sensitive,and can control the quality of the preparation effectively.
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1 ChP(中国药典).2005.Vol Ⅱ(二部)：120
2 MA Ke-qin(马克勤)，HUANG Guan-wen(黄冠文).Suggestion on the solvent for content determination of metoclopramide tablets(对甲氧氯普胺片含量测定用溶剂的建议).Drug Stand China(中国药品标准)，2006，7(4)：67
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