溴米那普鲁卡因注射液有关物质检验方法的研究___
Study on the detection of Related Substances of Bromisoval and Procaine Injection
分类号：
出版年·卷·期（页码）：2009,29 (12):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的：建立溴米那普鲁卡因注射液有关物质检测方法。方法：用LC/UV、LC/MS/MS对未知杂质进行了定性、定量研究。结果：建立了复方制剂有关物质检测方法，溴米那普鲁卡因注射液有关物质主要由溴米索伐引起，并确定了3个未知杂质的可能结构。结论：本法可用于溴米那普鲁卡因注射液有关物质的检测。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To develop a method for the determination of related substances in Bromisoval and Procaine injection.Method:LC/UV and LC/MS/MS were carried out for qualitative and quantitative researches of unknown impurities.Results:A method for related substances detection of compound preparation was established.The related substances are mainly caused by Bromisoval.The structures of three impurities were initially confirmed.Conclusion:The established method can be used for the determination of related substances in Bromisoval and Procaine Injection.
-----参考文献：---------------------------------------------------------------------------------------
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739th Session of the subcommittee planning and programming of the executive committee,Washington,2005
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