莪术醇对照品的主要有关物质分析___
Analysis of the related substance in reference substance of curcumol
分类号：
出版年·卷·期（页码）：2009,29 (8):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的：鉴定化学对照品莪术醇中的主要有关物质。方法：采用LC－MS/MS联用法，以SHIMADZU VP-ODS柱（150 mm×4.6mm，5μm）为色谱柱，乙腈-0.1%醋酸溶液（85﹕15）为流动相，以APCI为离子源，采用一级、二级质谱全扫描方式，对莪术醇对照品中的有关物质进行色谱分离及质谱鉴定。结果：通过对分子质量、二级质谱碎片信息和液相保留时间三方面信息，与对照品比较，证明莪术醇对照品中的有关物质为异莪术烯醇。结论：为莪术醇对照品的标化和提纯提供了依据。
-----英文摘要：---------------------------------------------------------------------------------------
Objective:To identify the related substance of curcumol.Methods:LC-MS/MS was adpopted to separated and identify he related substance of curcumol.The separation was performed on a C18 column and consist of 0.1%acetic acid –acetonitrle(85:15),the mass spectrometer was operated on APCI and two scan modes including full scan MS and full scan MS/MS.The obtained mass spectra were analyzed for their fragmentation passways. Results:The obtained mother ions ,fragment ions and the retention time were adopted to identify the related substance of curcumol,which was isocurcumenol. Conclusion: It provides the basis for purification and standardized of curcumol reference substance .
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1 ChP(中国药典).2005.Vol Ⅰ(一部):279
2 ChP(中国药典).2005.Vol Ⅱ(二部):591
3 Seiichi Inayama，Ji-Fu Gao，Kenzo Harimaya，et al．The absolute stereostructure of curcumol．Chem Pharm Bull，1984，32（9）：378
4 PENG Bing-xian(彭炳先)， ZHOU Xin(周 欣)， WANG Dao-ping(王道平)，et al．Studies on the Chemical Constituents of the Curcuma Phaeocaulis Valeton (中药蓬莪术化学成分的研究). Lishizhen Med Mater Med Res(时珍国医国药)，2005，3（11）：587
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