溶液pH、温度和光照等因素对盐酸阿比朵尔稳定性影响的考察___

摘要  目的：考察溶液pH、温度和光照等因素对盐酸阿比朵尔稳定性的影响。方法：采用液相色谱/质谱联用法对盐酸阿比朵尔溶液在上述试验因素作用下的浓度变化进行随时监测。将溶液浓度的变化和时间做回归分析，求得盐酸阿比朵尔在各试验条件下的降解曲线方程，利用降解速率常数来反映各因素对盐酸阿比朵尔稳定性作用的敏感程度。结果：盐酸阿比朵尔在酸性环境下稳定性良好；对碱、高温和光照敏感，且其在上述试验条件下发生降解时呈一级动力学规律趋势。结论：碱、高温和光照均对盐酸阿比朵尔溶液的稳定性有较大影响。

关键词：盐酸阿比朵尔；稳定性；pH；温度；光照

Abstract  Objective：To investigate the influence of pH,temperature and light on stability of arbidol hydrochloride.Method:An adjusted HPLC/MS method was employed to determine concentration loss of arbidol hydrochloride under these experimental factors mentioned above.The degradation calculations of arbidol hydrochloride under these experimental conditions were obtained by regulation analysis between proportion of the remaining and time,whose slopes indicated the sensitivity of the drug stability to these influencing factors.Result：Acid environment was helpful for arbidol hydrochloride stability;while basic condition,high temperature and sunlight could accelerate its decomposition.When the degradation began,it fitted a first-order process.Conclusion：Arbidol hydrochloride is unstable under basic condition,high temperature and sunlight.

Key words:arbidol hydrochloride;stability;pH;temperature;light