HPLC法测定盐酸吗啉胍注射液的有关物质及含量___
HPLC determination of the content and the related substances of moroxydine hydrochloride injection
分类号：
出版年·卷·期（页码）：2009,29 (4):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
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-----英文摘要：---------------------------------------------------------------------------------------
Abstract Objective: To establish an RP-HPLC method to the content and the related substances of moroxydine hydrochloride injection. Method: Use a C18（150mm×4.6mm, 5μm）column and 0.02 mol·L-1 sodium heptanesulfonate–methanol – acetonitrile（85︰5︰10） as the mobile phase at the flow rate of 1.0 mL·min-1. The detection wavelength was 237 nm. Results: The linear range was 1.002 - 200.40μg· mL-1(r2 =0.9999), the limit of the detection was 0.1μg·mL-1; the average recoveries were 98.88%, 101.29%, 100.65%( RSD = 1.8%, 1.0%, 1.4%). Conclusion: The method is simple, accurate, sensitive and reliable for determination of moroxydine hydrochloride injection.
-----参考文献：---------------------------------------------------------------------------------------
1 TAO Xian-shui（陶仙水）. Analytical Method of Moroxydine Hydrochloride(盐酸吗啉双胍分析方法研究). Shan xi Chem Ind(山西化工)，2002, 22(1): 46
2 Drug Standards of China（国家药品标准）. WS-10001-(HD-0651)-2002
3 Drug Standards of China（国家药品标准）. WS-10001-(HD-0649)-2002
4 DU Bin（杜斌），ZHANG Qiu-rong（张秋荣），SHEN Guo-peng（沈国鹏）. RP-HPLC assay for the determination of moroxydine hydrochloridi in compound metamizole sodium injection（反相离子对色谱法测定盐酸吗啉双胍的含量）. J Zhengzhou Univ(Med Sci)[郑州大学学报（医学版）]，2003，38（3）：416
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