复合膜包装对清喉利咽颗粒中挥发性成分薄荷脑的吸附研究

目的：建立薄荷脑的气相色谱含量测定方法，以考察复合膜包装对清喉利咽颗粒中挥发性成分薄荷脑的吸附。方法：采用HP-Innowax毛细管柱（长30 m，柱径0.25 mm，涂布厚度0.15μm），柱温110℃，进样口温度200℃，检测器温度220℃，载气为氮气，流速1.0 mL·min^-1，分流比10：1。结果：薄荷脑在0.7816~19.5400μg·mL^-1浓度范围内与峰面积呈良好的线性关系（r²=0.9999），复合袋包装上转移的薄荷脑回收率为94.2%，清喉利咽颗粒中薄荷脑回收率为94.0%；12个单剂量包装药品中，迁移至复合膜包装袋上的薄荷脑含量占药品总量比为31.9%~58.2%，平均45.6%。结论：清喉利咽颗粒的复合膜袋包装对其挥发性成分薄荷脑存在较大的吸附。  

Objective: To establish a GC method for determination of menthol, so as to investigate the adsorption of volatile component menthol in composite packing bag of Qinghou Liyan granules. Methods: The HP-Innowax capillary column (30 m×0.25 mm×0.15 μm)was used. The column temperature was 110℃, the inlet temperature was 200℃ and the detector temperature was 220℃. Nitrogen was selected as the carrier gas with a flow rate of 1.0 mL·min^-1 and the split flow ratio was 10:1. Results: Menthol showed good linearity of menthol at concentration of 0.781 6-19.540 0 μg·mL^-1 (r²=0.999 9). The recoveries of menthol in composite packing bag and in granules were 94.2% and 94.0%, respectively. In 12 single dose packaging drugs, the menthol in composite packing bag accounted for 31.9%-58.2% of the total and the average was 45.6%. Conclusion: There is a significant adsorption of menthol in composite packing bag of Qinghou Liyan granules. 

[1] 中华人民共和国药典2015年版. 一部[S]. 2015:1562 ChP 2015. Vol Ⅰ[S]. 2015:1562
[2] 陈光亮,佘玉宝,李冬梅. 薄荷油及其有效成分药理作用的研究概况[J]. 中国中医药信息杂志,2000, 7(2):33 CHEN GL,SHE YB,LI DM. A survey of the pharmacological effects of menthol oil and its active ingredients[J]. Inf Tradit Chin Med, 2000, 7(2):33
[3] 陈金通,陈鸿清,姚梅坤. 薄荷脑和樟脑促透作用的比较[J]. 海峡药学, 1999,11(3):59 CHEN JT, CHEN HQ, YAO MK. Comparison of penetration promoting effects of menthol and camphor[J]. Strait Pharm J, 1999, 11(3):59
[4] 董文燊,林芝,邵留英. 促透皮吸收剂对菌克软膏中盐酸林可霉素和醋酸地塞米松透皮吸收研究[J]. 解放军药学学报, 2017, 33(1):68 DONG WS, LIN Z, SHAO LY. Effects of penetration enhancers on percutaneous permeability of lincomycin hydrochlorideand and dexamethasone acetate in Junke Cream[J]. Pharm J Chin People's Lib Army,2017, 33(1):68
[5] 国家药包材标准[S]. 2015:178 National Drug Packaging Standard[S]. 2015:178
[6] 陈方亮,程亚军. 聚丙烯输液袋对两种平喘药物吸附性质的考察[J]. 中国药业, 2005, 14(11):50 CHEN FL, CHENG YJ. Study on the adsorption properties of polypropylene infusion bags for two antiasthmatic drugs[J]. China Pharm,2005, 14(11):50
[7] 赵永新,杨志毅,徐乃焕. PVC输液袋对胰岛素的吸附作用[J]. 中国医院药学杂志, 2000, 20(10):634 ZHAO YX, YANG ZY, XU NH. Adsorption of insulin by PVC infusion bag[J]. Chin J Hosp Pharm,2000, 20(10):634
[8] 张强,严文超,韩丽萍. 3层共挤输液用袋对6种药物的吸附性试验[J]. 中国药业, 2012, 21(22):64 ZHANG Q, YAN WC, HAN LP. Adsorption test of three-layer coextruded infusion bags on 6 kinds of drug[J]. China Pharm,2012, 21(22):64
[9] 赵冰,张顺亮,王守伟. 不同包装材料对肉制品模拟物中苯并(α)芘的吸附效果[J]. 肉类研究, 2018, 32(1):36 ZHAO B, ZHANG SL, WANG SW. Adsorption of Benzo(α) pyrene in meat simulants by different packaging materials[J]. Meat Res,2018, 32(1):36
[10] 孙一超,卢立新. 食品中不同种类风味物质对LDPE吸附现象的影响研究[J]. 包装工程, 2013, 34(1):34 SUN YC, LU LX. Effect of flavor compound kinds on absorption behavior of LDPE film[J]. Pack Engin,2013, 34(1):34
[11] 王露,丁小婷,陈凯. 活性炭的吸附机理评述[J]. 科学大众(科学教育),2018, 12:30 WANG L,DING XT,CHEN K. Review on adsorption mechanism of activated carbon[J]. Popul Sci,2018, 12:30
[12] 闫柯乐. 不同类型硅胶对油气吸附性能对比实验研究[J]. 石油科学通报, 2016, 1(3):434 YAN KL. Comparative experimental study on oil and gas adsorption properties of different types of silica gels[J]. Petrol Sci Bull,2016, 1(3):434
[13] 张全兴,李爱民,龙超. 新型树脂吸附剂对芳香性有机污染物的吸附作用机理及其应用[C]. 大连:中国化学会(持久性有机污染物论坛2007暨第二届持久性有机污染物全国学术研讨会论文集), 2007 ZHANG QX,LI AM,LONG C. Adsorption Mechanism of New Resin Adsorbent for Aromatic Organic Pollutants and Its Application[C]. Dalian:Chinese Chemical Society(Forum on Persistent Organic Pollutants 2007 and the Second National Symposium on Persistent Organic Pollutants),2007
[14] 李文臣,温冬梅. 高分子材料微观形态结构的扫描电镜研究[J]. 弹性体,2014, 24(6):78 LI WC,WEN DM. Study on the microstructure of polymer materials by scanning electron microscopy[J]. China Elastom,2014,24(6):78
[15] 常玉红,姜进宪,邴淑秋. 用扫描电镜技术观察交联聚乙烯的微观结构[J]. 橡塑技术与装备, 2010, 36:33 CHANG YH, JIANG JX, BING SQ. The microstructure of crosslinked polyethylene observed by scanning electron microscopy[J]. China Rubb Plast Technol Equip,2010, 36:33