[1] RAMAN A, LAU C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)[J]. Phytomedicine, 1996,2(4):349
[2] 汤琴,邓媛元,张雁,等. 苦瓜对肿瘤细胞的抑制作用及其活性成分研究进展[J]. 广东农业科学,2014, 41(13):104 TANG Q, DENG YY, ZHANG Y, et al. Research progress on the active composition and mechanism for anti-tumor effects of Momordica charantia L.[J]. Guangdong Agric Sci,2014,41(13):104
[3] MENSING H, ALBINI A, KRIEG T, et al. Enhanced chemotaxis of tumor-derived and virus-transformed cells to fibronectin and fibroblast-conditioned medium[J]. Int J Cancer,1984, 33(1):43
[4] ALBINI A, BENELLI R. The chemoinvasion assay:a method to assess tumor and endothelial cell invasion and its modulation[J]. Nat Protoc, 2007, 2(3):504
[5] WANG H, ZHANG H, TANG L, et al. Resveratrol inhibits TGF-β1-induced epithelial to mesenchymal transition and suppresses lung cancer invasion and metastasis[J]. Toxicology 2013, 303:139
[6] GUPTA GP,MASSAGUÉ J. Cancer metastasis:building a framework[J]. Cell, 2006,127(4):679
[7] LI F, LIU Y,KAN X, et al. Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis[J]. Pathol Res Pract, 2013, 209(2):105
[8] SALVO E, GARASA S, DOTOR J, et al. Combined targeting of TGF-beta1 and integrinbeta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer[J]. Mol Cancer,2014, 13:112
[9] 张绪忠,陈青山,程光文. 苦瓜抗菌作用的研究[J]. 中草药, 1995,26(10):556 ZHANG XZ, CHEN QS, CENG GW. Studies on antibacterial functions of Momordica charantia [J]. Chin Tradit Herb Drugs, 1995,26(10):556
[10] LAW LK, TAM PP, YEUNG HW. Effects of alpha-trichosanthin and alpha-momorcharin on the development of peri-implantation mouse embryos[J]. J Reprod Fertil, 1983, 69(2):597
[11] KIKUCHI T, ZHANG J, HUANG Y, et al. Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia [J]. Chem Biodivers, 2012, 9(7):1221
[12] 王先远,蒋与刚. 苦瓜皂甙的抗氧化作用初探[J]. 解放军预防医学杂志,2001, 19(5):317 WANG XY,JIANG YG. Study on anti-oxidant effects of Momordica saponin[J]. J Prev Med Chin PLA, 2001, 19(5):317
[13] OKADA Y, OKADA M, SAGESAKA Y. Screening of dried plant seed extracts for adiponectin production activity and tumor necrosis factor-alpha inhibitory activity on 3T3-L1 adipocytes[J]. Plant Foods Hum Nutr, 2010,65(3):225
[14] TSAO SW, NG TB, YEUNG HW. Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines[J]. Toxicon, 1990, 28(1):1183
[15] NG TB, LIU WK, SZE SF, et al. Action of α-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines[J]. Gen Pharmacol,1994, 25(1):75
[16] 沈富林,曹东亮,邓斐,等. α-苦瓜素体内抗人乳腺癌MCF-7移植瘤实验[J]. 成都医学院学报2014, 9(6):686 SHEN FL, CAO DL, DENG F, et al. The Anti-tumor experiments of alpha-momorcharin on human breast cancer MCF-7 xenograft in vivo[J]. J Chengdu Med Coll,2014, 9(6):686
[17] DENG NH, WANG L, HE QC,et al. PEGylation alleviates the nonspecific toxicities of alpha-momorcharin and preserves its antitumor efficacy in vivo[J]. Drug Deliv, 2016,23(1):95
[18] MATSUI Y, HADA T, MAEDA N, et al. Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth[J]. Cancer Lett, 2009, 283(1):101
[19] SCHULTE-HERMANN R, BURSCH W, GRASL-KRAUPP B, et al. Apoptosis and multistage carcinogenesis in rat liver[J], Mutat Res, 1995,333(1-2):81
[20] WANG P, HUANG S, WANG F, et al. Cyclic AMP-response element regulated cell cycle arrestsin cancer cells[J]. PLoS One, 2013,8(6):e65661
[21] LIU F, WANG B, WANG Z, et al. Trichosanthin down-regulates Notch signaling and inhibits proliferation of the nasopharyngeal carcinoma cell line CNE2 in vitro [J]. Fitoterapia,2012,83(5):838
[22] CHAO CY,HUANG CJ. Bitter gourd (Momordica charantia )extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4ⅡEC3 hepatoma cells[J]. J Biomed Sci, 2003, 10(6 Pt 2):782
[23] KOBORI M, NAKAYAMA H, FUKUSHIMA K, et al. Bitter gourd suppresses lipopolysaccharide-induced inflammatory responses[J]. J Agric Food Chem, 2008,56(11):4004
[24] XIONG SD, YU K, LIU XH, et al. Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells[J]. Int J Cancer, 2009,125(4):774
[25] GROSSMANN ME, MIZUNO NK, DAMMEN ML, et al. Eleostearic acid inhibits breast cancer proliferation by means of an oxidationdependent mechanism[J]. Cancer Prev Res(Phila),2009,2(10):879
[26] BAO B, CHEN YG, ZHANG L, et al. Momordica charantia (Bitter Melon)reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues[J]. PLoS One, 2013, 8(12):e84075
[27] BABISH JG, PACIORETTY LM, BLAND JS, et al. Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice[J]. J Med Food, 2010,13(3):535
[28] 熊术道,尹丽慧,李景荣,等. 苦瓜籽核糖体失活蛋白对肝癌H22细胞的抑制作用及其机制[J]. 山东医药, 2007,47(17):21 XIONG SD,YIN LH,LI JR,et al. Inhibitory action and mechanisms of RIP from Momordica charantia seeds on H22 hepatoma[J]. Shandong Med J, 2007,47(17):21
[29] 程霜,崔庆新,王勇. 水溶性苦瓜多糖的提取与测定[J]. 郑州粮食学院学报, 2000, 21(2):53 CHENG S, CUI QX, WANG Y. Extraction and determination of water-soluble polysaccharide of Momordica charantia L.[J]. J Zhengzhou Grain Coll, 2000, 21(2):53
[30] 张瑜,崔炯谟,赵余庆. 苦瓜抗肿瘤研究进展[J]. 中国现代中药, 2009, 11(1):4 ZHANG Y, CUI JM, ZHAO YQ. Progress on anti-tumorof Momordica charantia L.[J]. Mod Chin Med, 2009, 11(1):4
[31] CHAN WY, TAM PP, CHOI HL, et al. Effects of momorcharins on the mouse embryo at the early organogenesis stage[J]. Contraception, 1986, 34(5):537
[32] BIAN X, SHEN F, CHEN Y, et al. PEGylation of alphamomorcharin:synthesis and characterization of novel anti-tumor conjugates with therapeutic potential[J]. Biotechnol Lett,2010, 32(7):883
