近红外高光谱成像技术在药物分析中的研究进展

高光谱成像作为一种新型的光谱测量方法，比传统的光谱测量技术有着显著的优势，可同时获取被测试样的光谱信息及空间信息，且测量数据包含的信息量庞大，能更加准确地反映被测试样的整体性质。高光谱成像技术结合有效的化学计量学方法，可以对试样进行快速、无损分析，而且有利于深入研究试样的物理化学属性，现已广泛应用于生物、材料及医药领域的各项研究。本文系统地介绍近红外高光谱成像系统的测量原理、方式、数据结构及数据处理方法，并通过介绍该项技术在药物分析中的应用实例，对其在药物分析中的应用特点、范围及发展现状进行综述。

Hyperspectral imaging, as a new measuring method of spectrum, has obvious advantage over traditional spectral measurement techniques. With this new technique, the spectral information and spatial information of the tested samples can be obtained simultaneously, and data from measurement contains enormous information. Therefore it can reflect the global property of samples more accurately than traditional methods. In combination with the effective chemometrics method, hyperspectral imaging technique can be used for rapid and non-destructive analysis of the tested samples and is useful for further study of the physical and chemical properties of samples. Nowadays, it has been widely applied in biological, material and medical research fields. This paper introduces the measuring principle and mode, data structure and data processing method of the near-infrared hyperspectral imaging system. By presenting its application in the pharmaceutical analysis, the paper also reviews the range, characteristics and recent development of hyperspectral imaging technique in the pharmaceutical analysis.