药物酚磺乙胺在MnO2/离子液体复合电极上的电化学行为研究及测定
Study on electrochemical behaviors of ethamsylate and its analytical application at MnO2/ionic liquid modified electrode
分类号:
出版年·卷·期(页码):2011,31 (6):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
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目的: 制备 PF6-MnO2-CHIT/GCE修饰电极,研究酚磺乙胺(ETH)在该电极上的电化学行为及其测定方法。 方法: 循环伏安法和微分脉冲伏安法。 结果: ETH在 PF6-MnO2-CHIT/GCE上的循环伏安图上出现1对灵敏、可逆的氧化还原峰,其氧化峰电流响应是其在MnO2-CHIT/GCE上的2.8倍,峰电位差降低到0.029 V,电子转移速率常数Ks=0.283 s-1。ETH在 PF6-MnO2-CHIT/GCE上的微分脉冲伏安扫描峰电流与其浓度在5.0×10-7~5.0×10-4 mol·L-1范围内呈良好的线性关系,检出限为5.0×10-8 mol·L-1。连续5次测定1.0×10-5 mol·L-1酚磺乙胺溶液的RSD为1.8%。 结论: 本法可靠、快捷、灵敏,可用于酚磺乙胺注射液中酚磺乙胺含量的电化学定量测定,结果满意。
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Objective: To fabricate PF6-MnO2-CHIT/GCE modified electrode,the electrochemical behavior and determination of ethamsylate (ETH) on the electrode were investigated. Methods: Cyclic voltammetry and differential pulse voltammetry. Results: The cyclic voltammetry curves of ETH at PF6-MnO2-CHIT/GCE electrode present a pair of sensitive and reversible redox peaks.The peak current response at the proposed electrode enhances 2.8 folds higher than that at the MnO2-CHIT/GCE,and the peak potential difference is down to 0.029 V,electron transfer rate constant was Ks=0.283 S-1.The differential pulse voltammetry peak current of ETH in PF6-MnO2-CHIT/GCE showed good linear relationship in the range of ETH concentration of 5.0×10-7-5.0×10-4 mol·L-1,with a detection limit of 5.0×10-8 mol·L-1.The relative standard deviation of 1.0×10-5 mol·L-1 ETH was 1.8% for 5 consecutive measurements. Conclusion: The proposed method can be applied in ETH electrochemical determination with fast speed,high sensitivity and satisfied results.
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