维生素B12有关物质检查方法的探讨___
Discussion on the examine method of related substances in Vitamine B12
分类号：
出版年·卷·期（页码）：2010,30 (3):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的：改进中国药典2005年版二部维生素B12有关物质检查的方法。方法：采用不小于25的分离度保证系统适用性,流动相为甲醇-磷酸盐缓冲液pH 35(26∶74),检测波长为361 nm。结果与结论：新法的实用性、适用性和专属性等较原方法均有明显改善,推荐新版药典收载。
-----英文摘要：---------------------------------------------------------------------------------------
AbstractObjective:To improve the examine method of related substances for Vitamine B12 in ChP 2005Method:The resolution of not less than 25 was adopted to ensure the system suitability.The mobile phrase consisted of methanol-phosphate buffer solvent pH 35 (26∶74).The detection wavelength was 361 nm.Results and Conclusion:The new examine method was more practicable,applicable and specific,and was recommended to be adopted in the new edition of Chinese Pharmacopoeia.
-----参考文献：---------------------------------------------------------------------------------------
1LU Jie(鲁杰),YANG Da-jin(杨大进),WANG Zhu-tian(王竹天).Review of chemical methods for determining cyanocobalamin(维生素B12化学分析法研究概况).Chin J Food Hyg（中国食品卫生杂志),2003,15(3):248
2ChP (中国药典).2005.Vol Ⅱ (二部):668
3USP.32.2036
4JP.15.548
5EP.6.0.1630
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