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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nifdc.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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反相离子对色谱法测定2,5-二羟基苯磺酸盐及有关物质___

Ion-pair-RP-HPLC determination of dobesilates and their related substances

分类号:
出版年·卷·期(页码):2010,30 (1):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
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-----英文摘要:---------------------------------------------------------------------------------------

Objective:To establish an ion-pair-RP-HPLC method for the determination of dobesilates(including calcium dobesilate and ammonium dobesilate) and their related substances.Methods:The separation was performed on a Kromasil 100-5C18 column(250 mm×4.6 mm,5 μm).The mobile phase was composed of acetonitrile-methyl alcohol-0.2% tetrabutyl ammonium bromide in 0.2% potassium dihydrogen phosphate solution(pH 3.10±0.05),(10∶25∶65).The detection was carried out with a UV detector and the detective wavelength was set at 260 nm.The flow rate was 10 mL·mL-1 and the column temperature was 30 ℃.Results:The calibration curves of calcium dobesilate and ammonium dobesilate were both linear between 20.0-500 μg·mL-1;The correlation coefficient were 0.9999,0.9998,separately.The corresponding least detection limits were 1.44 ng and 1.64 ng,separately.The precisions were good(RSD=0.21%,0.23%).Conclusion:The method is credible and the results of the determination are accurate.

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