赖诺普利在多壁碳纳米管修饰电极上的电催化氧化及其电分析方法___

目的：研究赖诺普利在多壁碳纳米管修饰玻碳电极上的电催化氧化及其电化学动力学性质，据此建立赖诺普利电化学定量测定方法。方法：采用循环伏安法、计时电流法、计时电量法及方波伏安法等电化学方法。结果：赖诺普利在玻碳电极上的直接电化学氧化十分迟缓，无氧化峰出现，而在多壁碳纳米管修饰玻碳电极上于0.663 V处出现一不可逆氧化峰，同时考察了实验条件的影响，测定了电极反应过程动力学参数，并用本方法对赖诺普利胶囊进行了定量测定，RSD在0.85%~2.0%之间，加样回收率在98.9%~103.6%之间。结论：多壁碳纳米管修饰玻碳电极对赖诺普利的电化学氧化有明显的催化作用，是一受扩散控制的不可逆电极过程，该方法可用于市售赖诺普利药品含量的电化学定量测定，方法操作简便快捷，测定结果令人满意。

Objective: To study the electrochemical behaviors and electrochemical kinetic of lisinopril at multi-wall carbon nanotube modified glassy carbon electrode(MWCNT/GCE), and establish an electrochemical quantitative analysis method. Methods: Cyclic voltammetry(CV), chronocoulometry(CC), chronoamperometry(CA) and square wave voltammetry(SWV) were tried for test. Results: The direct electrochemical oxidation of lisinopril was sluggish on GCE, no oxidation peak appeared. However, an irreversible oxidation peak appeared on MWCNT/GCE at 0.663 V. The influence of experimental conditions was investigated. The electron transfer coefficient α, diffusion coefficient D and the electrode reaction rate constant Kf were measured, which given the values of 0.88, 5.96×10^-5 cm²·s^-1 and 1.93×10^-2 s^-1, respectively. The quantitative determination of lisinopril content was investigated, the relative standard deviation was between 0.85%-2.0% and the recovery was in the range of 98.9%-103.6%. Conclusion: The experimental result indicates that MWCNT/GCE can catalyze the oxidation of lisinopril well, and it is a diffusion-limited electrochemical process for lisinopril at MWCNT/GCE. Furthermore, this method can be applied in the test of lisinopril content with simple manipulation.