LIBS光谱技术鉴别原料药或辅料中的金属元素

目的：建立简便、快速鉴别原料药或药用辅料中金属元素的激光诱导击穿光谱法（LIBS）。方法：以择几种含钠、钾、镁、钙、锌元素的原料药或药用辅料为模型，采用LIBS采集样品的原子光谱，基于原子光谱理论和NIST数据库，对166~800 nm波段范围内LIBS谱线进行辨识，鉴别样品中的金属元素。结果：获得的LIBS光谱中的特征谱线与样品中的金属元素一一对应。结论：LIBS光谱法是鉴别药物或药用辅料中金属元素的快速、准确、可靠的方法。

Objective: To establish a simple and rapid method to identify metal elements in active pharmaceutical ingredients (APIs) or pharmaceutical excipients by laser-induced breakdown spectroscopy (LIBS). Methods: Select several APIs or pharmaceutical excipients containing Na,K,Mg,Ca,Zn as models,and collect their LIBS spectra in 166-800 nm wavelength range.Based on the theoretical knowledge of atomic spectroscopy and the NIST database,spectra analysis,the metal elements existing in the samples were identified. Results: The characteristic spectral lines obtained from the LIBS spectra correspond to the metal elements in the samples. Conclusion: LIBS technique can be used as a rapid,accurate and reliable method for identification of metal elements in APIs and excipients.

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